摘要
目的测定哮喘急性发作期和哮喘缓解期患者脂联素水平,探讨脂联素在哮喘发病机制中的作用。方法收集2010年10月至2011年9月期间在上海市闵行区中心医院就诊的哮喘患者97例,其中急性发作期50例,缓解期47例,另选同期非吸烟健康体检者27例作为对照。用ELISA法检测血清脂联素与肿瘤坏死因子α(TNF-α)水平,同时测定肺功能(FEV1%pred、RV%pred),分析脂联素水平和TNF-α、肺功能之间的相关性。应用SPSS 19.0软件进行统计学分析,多组数据间比较采用单因素方差分析,采用Pearson相关分析进行相关性检验。结果哮喘急性发作期组血清脂联素浓度[(2.46±1.21)ng/mL]低于缓解期组[(3.79±0.96)ng/mL]和健康对照组[(9.64±4.88)ng/mL](P均<0.01),哮喘缓解期组血浆脂联素浓度低于健康对照组(P<0.01)。哮喘急性发作期组及缓解期组血清脂联素与TNF-α、RV%pred呈负相关(P<0.01),与FEV1%pred呈正相关(P<0.01)。结论哮喘患者血清脂联素水平降低,脂联素在哮喘中可能起保护作用。
Objective To measure the serum level of adiponectin and explore its clinical implication in patients with asthma in acute exacerbation and remission phase. Methods 97 patients with asthma were recruited, including 50 patients with asthma in acute exacerbation and 47 patients in remission phase from October 2010 to September 2011. 27 healthy nonsmoking volunteers of normal weight （BMI range of 18.5-24.9 kg/m2） were included as control. The concentrations of adiponectin and tumor necrosis factor alpha （TNF-α） in serum were measured by enzyme-linked immunosorbent assay （ELISA）. The lung function was tested in all subjects. The correlations between adiponectin, TNF-α and lung function were investigated. The data was analyzed using SPSS 19. 0 software. Variables were compared with one-way ANOVA. The correlations between variables were analyzed using Peason＇ s eorrelation eoefficient or Spearman correlation coefficient. Results Serum adiponectin level was signifieantly lower in the patients with asthma in acute exaeerbation[ （246±1.21 ）ng/mL] than that in the healthy subjects [ （9. 64±4. 88 ） ng/mL] and the patients in remission phase [ （3.79±0. 96）ng/mL] （P 〈 0. 01 ）, while serum adiponectin level was also significantly lower in the patients in asthma remission phase than that in the healthy subjects （P 〈 0. 01 ）. The serum adiponectin level in the patients with asthma in acute exacerbation or in asthma remission phase was negatively correlated with the serum TNF-α level （ P 〈 0. 01 ） , and was positively correlated with FEV1/predicted value （P 〈 0. 01 ）. Conclusions The serum adiponectin is reduced in asthma patients and may play a protective role in asthma.
出处
《中国呼吸与危重监护杂志》
CAS
2013年第5期451-453,共3页
Chinese Journal of Respiratory and Critical Care Medicine
基金
上海市医学重点专科建设项目(编号:ZK2012A23)
关键词
哮喘
脂联素
肿瘤坏死因子Α
Asthma
Adiponeetin
Tumor necrosis factor alpha
