摘要
目的探讨肥胖哮喘患儿血清脂肪因子chemerin水平改变及其临床意义。方法纳入100例哮喘急性发作期的肥胖患儿和60例健康肥胖患儿。分别于患儿入院当天和出院当天检测血清总氧化态(TOS)、总抗氧化态(TAS)、氧化应激指数(OSI)和chemierin水平。结果哮喘组患儿TAS明显低于对照组,差异有统计学意义(P<0.05);而TOS和OSI明显高于对照组,差异有统计学意义(P<0.05)。哮喘组出院时TOS和OSI水平低于入院时,差异有统计学意义(P<0.05)。入院时哮喘组chemerin水平明显高于对照组,差异有统计学意义(P<0.05),出院时哮喘组chemerin水平低于入院时,差异有统计学意义(P<0.05)。危重度亚组患儿入院时和出院时TOS、OSI和chemerin水平均明显高于轻度亚组患儿,差异均有统计学意义(P<0.05)。入院时chemerin水平诊断哮喘急性发作的受试者工作特征曲线下面积(AUC)为0.820。相关性分析提示chemerin与哮喘急性发作(r=0.658,P<0.05)和严重分级(r=0.608,P<0.05)呈正相关。Logistic回归分析提示OSI(OR=1.24,P<0.05)和chemerin(OR=1.54,P<0.05)是哮喘急性发作发生的独立危险因素。结论新型脂肪因子chemerin通过调控体内氧化应激水平参与到肥胖患儿哮喘急性发作的病理生理学机制,chemerin水平可以作为肥胖患儿哮喘急性发作潜在标记物。
Objective To estimate the clinical value of serum chemerin in fat children with asthma at acute stage.Methods Onehundred fat children with asthma at acute stage and sixty healthy fat children were enrolled in this study.The levels of total oxidation state（TOS）,total anti-oxidant state（TAS）,oxidative stress index（OSI）and chemerin were measured on the admission day and discharge day.Results The level of TAS in asthma group were significantly lower than those in control group（P〈0.05）,while TOS and chemerin in asthma group were significantly higher than those in control group（P〈0.05）.The levels of TOS,OSI and chemerin in asthma group on discharge day were significantly lower than those in admission day（P〈0.05）.The levels of TOS,OSI and chemerin in critical subgroup on both admission day and discharge day were significantly higher than those in control group（P〈0.05）.ROC analysis showed that the AUC of chemerin for diagnosis of asthma was 0.820.Correlation analysis showed that chemerin were positively associated with acute stage of asthma（r=0.658,P〈0.05）and severity（r=0.608,P〈0.05）.Logistic regression showed that OSI（OR=1.24,P〈0.05）and chemerin（OR=1.54,P〈0.05）were independent risk factors for acute stage of asthma.Conclusion Novel fatty factor,chemerin,may contribute to pathophysiological mechanism of asthma by mediating the levels of oxidative stress,which makes chemerin to be a marker for asthma with acute stage in fat children.
出处
《检验医学与临床》
CAS
2016年第22期3173-3176,共4页
Laboratory Medicine and Clinic
