摘要
目的探讨哮喘儿童血清环氧化酶-2（COX-2）、白细胞介素-8（IL-8）、GM-CSF的动态变化及其临床意义。方法应用双抗体夹心ELISA法检测86例哮喘患儿血清COX-2、IL-8、GM—CSF水平，其中发作期42例，缓解期44例，设正常对照40名。结果哮喘组血清COX-2、IL-8、GM-CSF水平均高于对照组（P〈0．05）；哮喘急性发作期血清COX-2、IL-8、GM—CSF水平亦均高于缓解期（P〈0．05）。结论观察哮喘患儿血清中COX-2、IL-8、GM-CSF水平的变化，对探讨其发病机理，指导临床用药具有十分重要价值。
Objective To explore the changes of serum COX-2,IL-8 and GM-CSF levels in asthmatic children and their clinical significance. Methods The serum COX-2, IL-8 and GM-CSF levels of 86 asthmatic children, including 42 cases in the acute attack group and 44 cases in the remission group, and 40 healthy controls were detec- ted by sandwich ELISA. Results The serum COX-2 ,IL-8 and GM-CSF leyels in the asthmatic group significantly increased（P 〈 0. 05）. The serum COX-2 ,IL-8 and GM-CSF levels in the acute attack group were higher than these in the remission group（ P 〈 0. 05） ;the serum COX-2,IL-8 and GM-CSF levels in both acute attack group and remission group were higher than those in control group （ P 〈 0. 05 ）. Conclusions These cyt0kines participated in the patho- genesis of bronchial asthma. Monitoring the changes of their sermn levels was helpful for the management of the diseases. [ Key
出处
《中国基层医药》
CAS
2009年第11期1989-1990,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
哮喘
环氧化酶-2
白细胞介素-8
GM-CSF
儿童
Asthma
cyelooxygenase-2
lnterleukin-8
Granulocyte-macrophage colony stimulating factor （GM-CSF）
Child
