摘要
目的探讨缓解期克罗恩病患者血清25-羟基维生素D与炎性细胞因子白细胞介素-10(interleukin-10,IL-10)及肿瘤坏死因子-α(tumour necrosis factor-α,TNF-α)的关系。方法根据血清维生素D水平将35例缓解期克罗恩病患者分为维生素D缺乏组(A组)和维生素D充足组(B组),采用ELISA检测两组患者入组时及A组患者经补充维生素D治疗后的血清IL-10和TNF-α水平。结果 A、B两组患者血清TNF-α水平比较无统计学差异(P>0.05),A组患者血清IL-10水平显著低于B组(P<0.05);A组患者经补充维生素D治疗后血清IL-10和TNF-α水平与治疗前比较无统计学差异(P>0.05)。结论存在维生素D缺乏的克罗恩病患者循环IL-10水平显著降低,提示维生素D缺乏可能与这些患者的抗炎能力下降有关。
Objective To determine if serum 25-hydroxy-vitamin D was associated with inflammatory cytokines, interleukin-10 （IL-10）, and tumour necrosis factor-α（TNF-α） levels in patients with inactive Crohn’s disease （CD）. Methods 35 adults with quiescent CD were divided into vitamin D-insufifcient group （group A） and vitamin D-replete group （group B） according to serum 25-hydroxy-vitamin D levels. Then serum IL-10 and TNF-αlevel were detected by ELISA and compared. After vitamin D supplement to patients in group A, serum IL-10 and TNF-αlevels were detected again and compared to previous levels. Result Serum IL-10 levels of patients in group A were signiifcantly lower compared with group B （P〈0.05） while there were no differences in serum TNF-αlevels （P〉0.05）. The use of a vitamin D supplement did not signiifcantly inlfuence serum IL-10 and TNF-αlevel （P〉0.05）. Conclusions Circulating levels of IL-10, but not TNF-alpha, were signiifcantly lower in CD patients with inadequate serum 25-hydroxy-vitamin D. This suggests that poor vitamin D status may be linked to reduced anti-inlfammatory capacity in these
出处
《中国医药指南》
2013年第25期330-332,共3页
Guide of China Medicine
