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不同代谢途径他汀药物对氯吡格雷抗血小板作用的影响研究进展 被引量：1

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摘要 2003年,Lau等[1]研究指出经细胞色素(CYP)3A4途径代谢的他汀竞争性抑制氯吡格雷在体内的激活并降低其抗血小板活性,紧随其后至今大量有关他汀与氯吡格雷相互作用的研究,但结论不一。但他汀与氯吡格雷在治疗冠心病,特别是ACS患者中经常联用。最新指南指出对于无禁忌症的STEMI患者入院后应尽早开始强化他汀药物治疗,需阿司匹林与氯吡格雷双抗血小板[2]。本文就不同代谢途径他汀药物对氯吡格雷抗血小板作用的影响研究进展进行综述。
作者 谭钢文 吴同果
机构地区 广东省暨南大学第四附属医院 广州市红十字会医院
出处 《心血管病防治知识（学术版）》 2013年第9期85-88,共4页 Prevention and Treatment of Cardiovascular Disease
关键词 氯吡格雷 他汀类药物 抗血小板 CYP3A4 急性冠脉综合征
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献21

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二级参考文献17

  • 1Lau WC, Waskell LA, Watkins PB, et al. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug- drug interaction. Circulation, 2003,107: 32-37. 被引量：1
  • 2Zahno A, Brecht K, Bodmer M, et al. Effects of drug interactions on biotransformation and antiplatelet effect of clopidogrel in vitro. Br J Pharmacol, 2010,161 : 393-404. 被引量：1
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  • 10Lau WC, Waskell LA, Watkins PB, et al. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction [ J ]. Circulation, 2003,107 ( 1 ) : 32 - 37. 被引量：1

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心血管病防治知识（学术版）
2013年 第9期

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