摘要
目的:系统评价他汀类药物对我国原发性高血压患者的疗效。方法:计算机检索Cochrane图书馆、Pubmed、EMbase、中国生物医学文献光盘数据库、中国期刊全文数据库、维普中文科技期刊、万方数字化期刊群等数据库,全面收集他汀类药物对我国原发性高血压患者的疗效和安全性的随机对照试验(RCT)。评价纳入研究的方法学质量,提取有效数据,采用RevMan5.1统计学软件进行Meta分析。结果:总共纳入15项RCT,合计1241例患者。Meta分析结果显示,他汀类药物能显著降低原发性高血压患者的收缩压[MD=-6.38,95%CI(-9.70,-3.06),P<0.01]、舒张压[MD=-3.11,95%CI(-5.65,-0.57),P=0.02]、脉压[MD=-4.65,95%CI(-6.12,-3.19),P<0.01],同时能降低总胆固醇[MD=-1.33,95%CI(0.12,-0.54),P<0.01]、甘油三酯[MD=-0.33,95%CI(-0.44,,-0.23),P<0.01]、低密度脂蛋白[MD=-0.83,95%CI(-1.17,-0.48),P<0.01],升高高密度脂蛋白[MD=0.12,95%C(I0.05,0.18),P<0.01],与对照组比较差异有统计学意义。结论:他汀类药物对于原发性高血压疗效显著,安全性好。但由于纳入的研究数量有限,该系统评价的结果需谨慎对待,尚需更多的设计合理、多中心、大样本的RCT以进一步证实。
OBJECTIVE：To evaluate the efficacy and safety of statins in the treatment of essential hypertension.METHODS：Retrieved from Cochrane library,Pubmed,EMbase,CBM,CNKI,VIP and Wanfang database,RCTs about the efficacy and safety of statins in the treatment of essential hypertension were collected completely in China.Methodological quality of included studies was evaluated,and effective data was extracted.Rev Man 5.1 software was used for data analysis.RESULTS：A total of 15 RCTs were included,involving 1 241 patients.Results of Meta-analysis showed that statins could reduce the levels of SBP [MD=-6.38,95%CI（-9.70,-3.06）,P0.01],DBP[MD=-3.11,95%CI（-5.65,-0.57）,P=0.02] and PP [MD=-4.65,95%CI（-6.12,-3.19）,P0.01],at the same time they could reduce the level of TC [MD=-1.33,95%CI（0.12,-0.54）,P0.01],TG [MD=-0.33,95%CI（-0.44,,-0.23）,P0.01] and LDL-C[MD=-0.83,95%CI（-1.17,-0.48）,P0.01],while increase the level of HDL-C [MD=0.12,95%CI（0.05,0.18）,P0.01],there was significant difference between 2 groups.CONCLUSIONS：Statins are effective and safe in the treatment of essential hypertension.Because included studies are limited in quantity,results of the review want discretion and high-quality multiple-centered large-scale RCTs are required.
出处
《中国药房》
CAS
CSCD
2013年第20期1889-1893,共5页
China Pharmacy
