摘要
目的本文主要研究小牛血清去蛋白注射液对局灶性脑缺血大鼠脑血管储备能力的影响。方法随机将88只大鼠分为治疗组40只、缺血组40只、假手术组8只，治疗组在手术前的三天给予腹腔注射小牛血清去蛋白注射液，剂量为2毫升，一天一次，最后一次进药时间是手术前的五小时。在完成模后的三天内分别处死缺血组和治疗组，最后采取血管内皮生长因子（VEGF）的免疫组化检测。结果在手术后缺血的三小时，治疗组逐渐出现阳性反应，各时间点脑组织表达明显多于缺血组和假手术组，具有统计意义（P〈0．05）。结论小牛血清去蛋白注射液可以提高局灶性脑缺血大鼠脑血管储备能力，对缺血性脑损伤具有保护功能。
Objective This article mainly research the calf serum injection to protein game focal cerebral ischemia rats vascular reserve capacity. Methods 88 rats randomly divided into treatment group （40, ischemia group and 40, only control 8, only three days before the surgery treatment group given intraperitoneal injection of calf serum injection to prdtein, dose of 2 ml, once a day, the last time into the medicine time is five hours before surgery. Within three days after completion of mold executed ischemia group and treatment group respectively, and finally to vascular endothelial growth factor （VEGF） immunohistochemical detection. Results In the ischemia of three hours after the surgery, the treatment group developed positive reaction, brain tissue expression at each time point were significantly more than the ischemia group and control group, with statistical significance （P 〈 0.05）. Conclusion calf serum albumen injection can improve the focal cerebral ischemia rats vascular reserve capacity, has protective function on ischemic brain injury.
关键词
小牛血清去蛋白注射液
局灶性
脑缺血
大鼠脑血管
储备能力
The calf serum iniection to protein
Focal
Cerebral ischemia
Blood vessels in rats
Reserve capacity
