摘要
我国是食管癌高发的国家,发病人数超过全球的一半。研究者已经从流行病学、分子生物学、病理生理学和临床诊疗等多个方面对其进行了广泛的研究,但发病机制尚不明确。最近的大量研究发现,microRNA表达水平的改变与食管癌的发生发展、诊断、治疗和预后密切相关。该文就microRNA与食管癌的关系进行综述,帮助读者了解microRNA在该病发生过程中的重要作用,为食管癌的综合防治提供线索。
The ineidence of esophageal cancer is very high in China, and more than half of the global patients are Chinese. Epidemiological, biochemical, pathophysiological, and clinical studies have been performed. However, the mechanisms are still unclear. A wealth of recent studies find that the expression levels of microRNA are associated with the development, diagnosis, treatment and prognosis of esophageal cancer. To help the readers understand the importance of microRNA in the development of esophageal cancer, this review introduces current state of knowledge about the association between microRNA and esophageal cancer, and the underlying mechanisms.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2013年第9期1405-1411,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:30901216)
浙江省教育厅科研基金(批准号:Y201224146)
宁波市科技创新团队(批准号:2011B82014)资助的课题~~
