摘要
我国是食管癌高发国家,发病人数占全球一半以上,国内食管癌的死亡率为17.38/10万,居恶性肿瘤的第4位。miRNA是新发现的一种具有高度进化保守性的单链RNA,在转录后水平引起靶mRNA降解或翻译抑制。miRNA的表达水平与食管癌的类型、预后等密切相关。在外周血中,miRNA水平也表现出显著的肿瘤相关性、组织特异性和表达稳定性。随着食管癌发病率不断增加,人们更加关注食管癌的发病机制及早期分子生物学标志物的研究。
China is a country of high incidence of esophageal cancer, incidence accounted for more than half of the world, the esophageal cancer mortality rate was 17.38/10 million, ranking the fourth malignant tumor. miRNA is a highly evolutionary conservation of the single stranded RNA newly found, cause the target mRNA degradation or translational inhibition at the post transcriptional level. Abnormal expression of miRNA and esophageal cancer occurrence, differentiation, metastasis and recurrence are closely related. In the peripheral blood, miRNA also showed significant tumor correlation, tumor tissue specificity and tumor expression stability. With the increasing incidence of esophageal cancer, the molecular mechanism of esophageal cancer and early molecular biomarkers will research more deeply. This paper reviewed the study on expression of miRNA occurred in diagnosis and treatment and prognosis of esophageal cancer.
出处
《中国医药科学》
2014年第7期43-47,共5页
China Medicine And Pharmacy
