摘要
目的观察盐酸羟考酮缓释片口服给药与直肠给药2种途径治疗癌痛的疗效和不良反应。方法选择宜春市人民医院肿瘤科2012年2月至2013年2月收治的癌症晚期患者60例,按随机数字表法将60例患者分为口服给药组和直肠给药组,每组30例,比较2种给药途径的缓解疼痛的疗效、改善患者生活质量以及不良反应发生情况。结果口服给药组疼痛缓解有效率为93.3%,直肠给药组有效率为90.0%,疗效和生活质量的改善相当,2组比较差异无统计学意义(P>0.05);直肠给药组消化道不良反应低于口服给药组,2组比较差异有统计学意义(P<0.05)。结论直肠给药与口服给药止痛效果相当;直肠给药不良反应少,对于胃肠道梗阻、意识障碍的患者,不失为一种简单方便、安全有效的方法。
Objective To compare the curative efficacy and side effect of orally and rectally administered oxycodone hydrochloride controlled-release tablets in cancer-relate pain.Methods Sixty advanced cancer patients treated in Yichun People＇s Hospital between February 2012 and February 2013 were randomly administered oxycodone hydrochloride controlled-release tablets via oral route（oral administration group,n=30） or rectal route（rectal administration group,n=30）.Pain relief,quality of life and side effect were compared between the two groups.Results The effectiveness of pain relief was 93.3% in oral administration group and 90.0% in rectal administration group.There were no significant differences in the improvement in the efficacy and quality of life between the two groups（P〉0.05））.However,the incidence of gastrointestinal adverse reactions in rectal administration group was significantly lower than that in oral administration group（P〈0.05）.Conclusion There was no obvious difference in the effectiveness of pain relief between orally and rectally administered oxycodone hydrochloride controlled-release tablets.However,rectal administration has less adverse effects than oral administration.Therefore,rectal administration is simple,convenient,safe and effective for patients with gastrointestinal obstruction or conscious disturbance.
出处
《南昌大学学报（医学版）》
CAS
2013年第6期19-21,共3页
Journal of Nanchang University：Medical Sciences
基金
江西省科技厅重大项目(20111BBG70014-9)
关键词
盐酸羟考酮缓释片
癌痛
口服给药
直肠给药
oxycodone hydrochloride controlled-release tablets
cancer-relate pain
oral administration
rectal administration
