摘要
目的:观察丹蛭降糖胶囊对实验性糖尿病大鼠的降糖作用。方法:大鼠静脉注射链脲佐菌素致实验性糖尿病模型,随机分为模型组、盐酸苯乙双胍组(75 mg·kg-1)、糖脉康组(1.5 g·kg-1)和丹蛭降糖胶囊高、中、低剂量组(生药13,6.5,3.2 g·kg-1),每组8只,另选8只正常大鼠为正常对照组,给药20 d后,观察各组大鼠体重、血糖、糖耐量、糖化血红蛋白及胰岛素水平的变化。结果:丹蛭降糖胶囊高剂量组能显著降低糖尿病大鼠空腹血糖(P<0.01),改善糖耐量(P<0.01);各剂量组均能显著增加糖尿病大鼠的体重(P<0.01,P<0.01,P<0.05)、降低糖化血红蛋白水平(P<0.01,P<0.01,P<0.01);而不影响胰岛素水平。结论:丹蛭降糖胶囊对实验性糖尿病大鼠有显著降糖作用。
Objective：To investigate the anti-diabetic effect of Danzhi Jiangtang capsule（DJC） on experimental diabetic rats.Method：Experimental diabetic model in rats was induced by the injection of streptozocin.The models were divided randomly into 6 groups：model group（normal saline ig）,phenformin hydrochloride group（75 mg·kg-1,ig）,Tangmaikang group（1.5 g·kg-1,ig） and DJC low,middle,high dose（13,6.5,3.2 g·kg-1,ig） groups（n =8 each）.Rats were selected as normal group（nomal saline ig）.After 20 days of administration,effects of body weight,blood glucose,glucose tolerance and insulin level of rats were observed.Result：The DJC high dose group could significantly decrease level of fasting blood glucose（P ＆lt; 0.01） and improve glucose tolerance（P ＆lt; 0.01）.All the DJC groups could significantly increase body weight of diabetic rats（P ＆lt; 0.01,P ＆lt; 0.05） and decrease level of glycosylated serum protein（P ＆lt; 0.01）.No obvious effect of DJC on insulin level.Conclusion：DJC has significant anti-diabetic effect on experimental diabetic rats.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第17期288-290,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家"重大新药创制"科技重大专项(2010ZX09102-209)
国家中医药管理局新药开发专项课题(DIX025A)
关键词
丹蛭降糖胶囊
糖尿病
空腹血糖
糖耐量
糖化血红蛋白
胰岛素
Danzhi Jiangtang capsule
diabetes mellitus
fasting blood glucose
glucose tolerance
glycosylated serum protein
insulin
