摘要
目的:优选参玉口服液的澄清工艺。方法:以人参皂苷含量、总多糖含量、澄明度和稳定性为评价指标,考察KBT-ZTC絮凝澄清法、酶解法、微滤法、酶解-微滤法及絮凝澄清-微滤法对参玉口服液质量的影响。结果:最佳澄清处理方法为絮凝澄清-微滤法,参玉口服液澄清稳定、有效成分保留率得以提高,人参皂苷Re、人参皂苷Rg1、人参皂苷Rb1、总多糖质量分数分别为0.331 1,0.282 8,0.098 4,96.33 mg·g-1。结论:KBT-ZTC絮凝澄清法与微滤法联用能有效除去杂质,保留有效成分,且工艺稳定,可作为参玉口服液的澄清工艺。
Objective：To optimize clarification technology of Shenyu oral liquid.Method：Effects of KBT-ZTC flocculation,enzymatic,microfiltration,enzymatic-microfiltration and flocculation-microfiltration on quality of Shenyu oral liquid were investigated with the contents of ginsenoside and total polysaccharides,clarity and stability as evaluation indexes.Result：Optimum clarification method was flocculation-microfiltration which could improve retention rate of effective ingredients of Shenyu oral liquid and make this oral liquid clear and stable.The contents of ginsenoside Re,Rg1,Rb1 were 0.331 1,0.282 8,0.098 4 mg·g-1 and the content of total polysaccharides was 96.33 mg·g-1.Conclusion：Impurities could removed effectively and effective ingredients were retained by KBT-ZTC flocculation-microfiltration method,this process was stable and could be used as clarification technology of Shenyu oral liquid.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第17期4-7,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家科技重大专项(2011ZX09401-305)
国家科技支撑计划(2012BAI29B05)
吉林省医药产业发展专项(YYZX201134)
关键词
参玉口服液
澄清工艺
人参皂苷
多糖
澄明度
稳定性
Shenyu oral liquid
clarification process
ginsenosides
polysaccharides
clarity
stability
