摘要
几丁质酶样蛋白40（YKL-40）属于18糖基水解酶家族成员之一，由一些恶性细胞和非恶性细胞所分泌，几乎涉足人类的所有疾病，如肿瘤、感染、自身免疫以及代谢性疾病等，具有促进炎症、纤维化、组织重塑、肿瘤细胞生长以及拮抗凋亡等生物功能。同样，也参与了许多肺部疾病的病理生理过程，如支气管哮喘、慢性阻塞性肺疾病、特发性肺间质纤维化、结节病、肺癌等。本文就YKL-40参与的肺部疾病进行综述。
YKL-40 belongs to 18 glycosyl hydrolase family members, is secreted by some malignant and non-malignant cells, and involved in almost all human diseases, such as tumor, infection, autoimmune and metabolic diseases, etc. It has been proved to promote inflammation, fibrosis, tissue remodeling, cell growth, and inhibit apoptosis. In addition, YKL-40 is also involved in the pathophysiological process of many lung diseases, such as bronchial asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, lung sarcoidosis, etc. This article reviews the basic biological features of YKL-40 and its involvement in different lung diseases.
出处
《国际呼吸杂志》
2013年第14期1091-1095,共5页
International Journal of Respiration
基金
湖北省基金资助（2008CDBl21）
