摘要
抗菌肽是生物体先天性免疫系统的重要组成成分,是多种不同具有抗菌活性天然多肽分子的统称。研究发现抗菌肽具有抗包括G+细菌,G-细菌,真菌,支原体,病毒在内的多种病原体的广谱作用活性,有些抗菌肽还具有抗肿瘤活性。本文主要综述了抗菌肽的分类、作用机制、改造策略及其应用中存在的问题。
Antimicrobial peptides （AMPs） are key components of the innate immune system that constitute a diverse class of naturally occurring antimicrobial molecules. AMPs have been found to exhibit a broad range of activities against microorganisms, including Gram positive and Gram-negative bacteria, fungi, myeoplasma, and viruses. Some antibacteri al peptides also have antitumor activity. This review focuses on the classification of antibacterial peptides, their mecha- nisms of action, strategies for their transformation, and existing problems with their use.
出处
《中国病原生物学杂志》
CSCD
北大核心
2013年第7期659-663,共5页
Journal of Pathogen Biology
基金
山东省科技攻关计划课题(No.2008GG10002008)
关键词
抗菌肽
分类
作用机制
应用
综述
Antimicrobial peptide
classification
mechanism of action
use
review
