摘要
目的 探讨乳腺卵巢双原发癌的临床病理特征.方法 总结并分析27例乳腺卵巢双原发癌患者的家族史、发病年龄、临床分期、病理类型及生存情况.结果 27例患者中具有乳腺癌或卵巢癌家族史者8例,占29.6％；首次发病年龄小于50岁者12例,占44.4％；有家族史者首次发病年龄偏早.双原发癌中乳腺癌多为浸润性导管癌（18例,66.7％）,0～Ⅱ期者占92.6％（25例）；卵巢癌多为浆液性腺癌（13例,48.1％）.首发癌为乳腺癌的患者第二癌术后5年生存率为11.1％ （3/27）,首发癌为卵巢癌的患者第二癌术后5年生存率为7.4％ （2/27）；有乳腺癌或卵巢癌家族史者,第二癌术后5年生存率为3.7％（1/27）,无家族史的患者第二癌术后5年生存率为11.1％（3/27）.结论 有乳腺癌或卵巢癌家族史的乳腺卵巢双原发癌患者发病年龄早且预后较差；首发癌为卵巢癌的乳腺卵巢双原发癌患者预后较差.卵巢癌的病理学特征是影响乳腺卵巢双原发癌预后的主要因素.
Objective To explore the clinicopayhological features of double primary cancers of breast and ovarian.Methods Twenty-seven cases of double primary cancers of breast and ovarian were reviewed and analyzed in breast or ovarian cancer family history,age at onset of the first cancer,clinical stage,pathological patterns and survival rates.Results Eight cases（29.6%） of the 27 patients had breast or ovarian cancer family history,44.4% of the cases younger than 50 at onset of the first cancer,and the patients with the family history were younger at onset.Major pattern of the breast cancer was invasive ductal carcinoma（18 cases,66.7%）,92.6% of the cases were in stage 0-Ⅱ ; Major pattern of the ovarian cancer was serous adeno-carcinoma（13 cases,48.1%）.The 5-year survival rate after the 2nd operation of the patients with the breast cancer as the first cancer was 51.9%,and the number was 7.4% in the patients with the ovarian cancer as the first cancer.The 5-year survival rate after the 2nd operation of patients with family history was 3.7%,and the rate was 11.1% in non-family-history patients.Conclusions The patients of double primary cancers of breast and ovarian who have breast or ovarian cancer family history get the first cancer at a younger age and have worse prognosis.The patients with the ovarian cancer as the first cancer has worse prognosis,and the pathological features of the ovarian cancer influence the prognosis of the double primary cancers most.
出处
《中国医药》
2013年第8期1147-1149,共3页
China Medicine
关键词
乳腺肿瘤
卵巢肿瘤
双原发癌
家族史
Breast neoplasms
Ovarian neoplasms
Double primary cancer
Family history
