摘要
目的探讨δ-catenin在卵巢癌组织中的表达及临床意义。方法选取2005年1月至2008年8月在中国医科大学附属盛京医院手术切除的卵巢癌组织143例,并收集其临床病理特征。采用鼠抗人δ-catenin单克隆抗体以SP免疫组化法进行研究,并分析δ-catenin表达与临床病理因素的相关性。结果δ-catenin在11例正常卵巢组织中的表达为阴性或低表达,69.93%的卵巢癌(100/143)出现δ-catenin阳性表达,并且都是胞浆表达。δ-catenin表达阳性率在卵巢浆液性腺癌,子宫内膜样癌,黏液性腺癌和透明细胞癌中的阳性表达率分别为73.81%(62/84),67.57%(25/37),57.89%(11/19)和66.67%(2/3)。且δ-catenin在浆液性腺癌与其他类型卵巢癌中表达差异无统计学意义(阳性率分别为73.81%和64.40%,P=0.1957)。δ-catenin的表达在Ⅲ～Ⅳ期卵巢癌(Ⅲ期83.33%,Ⅳ期77.78%)中显著高于Ⅰ～Ⅱ期卵巢癌(Ⅰ期55.81%,Ⅱ期64.53%,P=0.0308)。结论δ-catenin在卵巢癌中过表达并且与FIGO分期正相关,δ-catenin可能成为卵巢癌诊断和治疗中的一个新靶点。
Abstract： Objective To examine and explore the expression and clinical significancy ofδ-catenin in human ovarian canc- ers. Methods 143 ovarian cancer specimens were obtained in Shengjing Hospital of China Medical University between 2005 January to 2008 August and their clinicopathologic factors were archived . The expression of δ-atenin and correlation with clinicopathologic factors were analyzed by using rat anti-human monoclonal antibody and SP immunohistochemistry. Results The expression of ^-catenin in ll normal ovarian tissues is negative or low expression. ^-catenin is overexpressed in 100 （69.93%） of the 143 patients and expressed in cytoplasma. The positive expression rates of 8-catenin in serous cys- tadenoma, endometrioid, mucinous cystadenoma and clear cell carcinoma are 73. 81% （ 62/84）, 67.57% （ 25/37 ）, 57.89% （11/19） and 66.67% （2/3） respectively. Fourthermore, there is no statistically difference between the expression of δ-catenin in serous cystadenoma and other types of ovarian cancer（73.81% ,64.40% respectively,P =0. 1957）. The ex- pression of δ-catenin in stage Ⅲ- Ⅳ ovarian cancers （ stage III, 83.33% ; stage 1V 77.78% ） is significantly higher than stage Ⅰ --Ⅱ （stage I, 55.81% ; stage Ⅱ, 64.53%, P = O. 0308）. Conclusion δ-catenin is overexpressed in ovarian canc- ers and associated with advanced stage.δ-catenin might be a potential diagnostic and therapeutic target of ovarian cancer.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2013年第1期43-45,共3页
Chinese Journal of Practical Gynecology and Obstetrics
