摘要
目的获取大鼠脑部的N-甲基-D-天门冬氨酸受体2A(NMDAR2A)表达强度分布的数据。方法通过免疫组织化学染色和图像分析,对成年雄性SD大鼠(n=6)不同脑区的NMDAR2A表达进行检测。结果得到大鼠全脑各主要结构NMDAR2A表达强度的数据,并绘制图谱。结论获得的NMDAR2A表达图谱可为原位检测鼠脑NMDAR2A的实验提供参考。
Objective N-methyl-D-aspartate receptor （NMDAR） is an important excitatory receptor within the central nervous system. Its 2A subunit is a critical functional subunit. There is no comprehensive data about NMDAR2A expression intensity in rat brain. Methods In this experiment, we detected NMDAR2a expression in the brain of adult male SD rat （n = 6 ） with immunohistoehemistry staining and image analysis. Results We drew the expression intensity atlas of rat brain based on the immunohistochemical staining intensity. Conclusion These data can provide a reference for in situ detection of NMDAR2A in related experiments.
出处
《解剖学报》
CAS
CSCD
北大核心
2013年第4期456-462,共7页
Acta Anatomica Sinica
基金
成都医学院校基金课题资助项目(CYZ09-006)
