摘要
目的探讨Gli-1蛋白在胃癌组织中的表达情况及临床意义。方法应用免疫组化SP法检测65例胃癌组织及16例癌旁正常组织中Gli-1蛋白的表达,并结合患者的临床资料进行分析。结果在胃癌组织中Gli-1蛋白阳性表达率为64.5%(40/62),高于相应正常组织的0(0/16),差异有统计学意义(P=0.000)。Gli-1蛋白阳性表达率与胃癌患者的不同组织学分级、临床分期和淋巴结转移状态间的差异具有统计学意义(P<0.05)。结论 Gli-1可能在胃癌的进展中起重要作用,其蛋白表达可以作为一项临床诊断的重要指标。
Objective To investigate the expression of Gli-1 protein in gastric cancer, and explore the relationship between the expression and tumor＇ s clinical and pathological characteristics. Methods The expression of Gli-1 protein was detected by immunohistochemical staining（SP） in 62 cases with gastric cancer and the matched normal gastric tissues, and the clinical data were analyzed. Results The positive rate of Gli-1 was 64.5% （40/62） in gastric cancer compared to the paired normal gastric tissues （0.0%） with statistical significance（ P = O. 0130） ;positive rate of Gli-1 was correlated with tumor grade, clinical stage and lymphatic invasion（ P 〈 0.05 ）. Conclusion Gli-1 may play a key rode in the progression of gastric cancer and might serve as an important target for therapeutic intervention.
出处
《中华全科医学》
2013年第9期1342-1343,1465,F0003,共4页
Chinese Journal of General Practice
基金
2010年度安徽省高校省级自然基金研究项目(KJ2010B121)
