摘要
目的探讨经皮下注射超声造影剂(SonoVue)在检测兔VX2肝癌前哨淋巴结(sentinel lymph nodes,SLNs)中的应用价值。方法建立兔VX2肝癌模型50只,分别种植在肝左叶(A组)及肝右叶(B组)。经皮下注射SonoVue,肝门部SLNs经超声造影显像,观察SLNs增强特点;经皮下在相同部位注射亚甲蓝(MB);行腹腔探查并清扫淋巴结,统计蓝染淋巴结的数量并送病理检查。结果以蓝染淋巴结为判定SLNs的标准,A、B两组SLNs经皮下超声造影的检出率分别为91.8%(34/37)、88.9%(32/36),两组间比较差异无统计学意义(P>0.05)。以病理结果为标准,经皮下注射超声造影剂判定肝门区前哨淋巴结转移与否的敏感性、特异性、准确性分别为90.5%(38/42)、79.2%(19/24)、86.3%(57/66),与病理结果有良好的一致性(K=0.703,P<0.001)。结论经皮下注射超声造影剂是检测肝癌前哨淋巴结的一种新方法,检测率与肝癌所在位置无关,并将在肝癌前哨淋巴结的识别、诊断中发挥重要作用。
Objective To investigate the application value for detecting sentinel lymphatic node （SLNs） in VX2 hepatic cancer rabbit by subcutaneous iniection SonoVue. Methods Fifty rabbit models of VX2 hepatic cancer in which 25 rabbit were set up in the left lobe （A group） and the remainder was set up in the right lobe（B group） were subcutaneously injec- ted with SonoVue to get contrast-enhanced ultrasound imaging of SLNs in porta hepatis. The characteristics of contrast- enhanced SLNs were observed. Methylene blue （MB） was injected in the same way as above. The lymph nodes dyed were taked out for recorded and pathologic examination. Results To make lymph nodes dyed as the standard,the detection rate of A group （91.8%, 34/37） and B group （88.9%, 32/36） showed no significant difference （ P 〈0.05）. To make pa thology as the standard, the sensitivity, specificity and accuracy of contrast-enhanced were 90.5 % （38/42）, 79.2 % （19/ 24）, 86.3%（57/66）, and showed well consistent with pathology （ K =0. 703, P d0. 001）. Conclusions Subcutaneous injection SonoVue whose detection rate has nothing with the position of tumor is new method to detect SLNs of hepatic cancer, which will play an important role in detecting and estimating SLNs of hepatic cancer.
出处
《医学影像学杂志》
2013年第7期1111-1114,共4页
Journal of Medical Imaging
关键词
超声造影
肝癌
淋巴结转移
前哨淋巴结
Contrast-enhanced ultrasound
Hepatic cancer
Lymph metastatic
Sentinel lymph nodes
