摘要
目的评价^18F—FDGPET／CT显像对脊柱单发转移瘤的诊断效能及优势。方法回顾性分析67例[男41例，女26例，年龄40～83（61．5±10．2）岁]有恶性肿瘤病史且经局部CT和（或）MRI检查发现单个椎体病变，疑为骨转移瘤患者的资料。患者均行PET／CT显像，既往未行MRI检查者于PET／CT检查后1周内行病变椎体MRI检查。脊柱单发病灶以病理学诊断或6个月以上影像学及临床随访作为最终诊断依据，将PET／CT融合图像与单纯PET、CT及MRI图像分别对比，评价PET／CT显像对脊柱单发转移瘤的诊断效能及优势。对数据行，检验。结果PET／CT显像诊断脊柱单发转移瘤的灵敏度为96．3％（52／54），特异性为84．6％（11／13），阳性预测值为96．3％（52／54），阴性预测值为84．6％（11／13），准确性为94．0％（63／67）。灵敏度、阴性预测值及准确性与PET[81．5％（44／54）、44．4％（8／18）、77．6％（52／67）]相比差异均有统计学意义（，值分别为6．000、5．134、7．421，均P〈0．05）；灵敏度、特异性、阴性预测值、准确性与CT[79．6％（43／54）、53．8％（7／13）、38．9％（7／18）、74．6％（50／67）]相比差异有统计学意义（，值分别为7．083、4．248、6．482、9．543，均P〈0．05）；准确性与MRI[80．6％（54／67）]相比差异有统计学意义（，=5．457，P〈0．05）。结论PET／CT对脊柱单发转移瘤有较高的诊断效能及优势。PET／CT准确性高于MRI，当在MRI怀疑脊柱单发转移难以明确性质时，可以通过PET／CT提高诊断准确性。
Objective To evaluate the efficacies and advantages of ^18F-FDG PET/CT in detection of single spinal metastasis. Methods A total of 67 patients （41 males, 26 females, with age range of 40 - 83 years, mean （61.5 ±10.2） years） with history of primary cancer and suspected single spinal metastasis by CT and/or MRI were enrolled into this retrospective study. All patients underwent ^18F-FDG PET/CT. The final diagnosis was confirmed by pathological results or follow-up（ 1〉6 months）. The efficacies of PET/CT imaging in detection of single spinal metastasis were compared with PET, CT and MRI. X^2 test was used to analyze data. Results The sensitivity, specificity, positive predictive value, negative predictive value and accuracy for PET/CT imaging were 96.3 % （52/54） , 84.6% （ 11/13 ）, 96.3 % （52/54）, 84.6% （ 11/13 ） and 94.0% （63/67） , respectively. The sensitivity, negative predictive value and accuracy of PET/CT imaging were better than those of PET （ 81.5 % （44/54）, 44.4% （ 8/18 ）, 77.6% （52/67） ; X^2 = 6. 000, 5. 134, 7.421, all P〈0.05） or CT （79.6% （43/54）, 38.9% （7/18）, 74.6% （50/67） ; X^2 =7. 083, 6. 482, 9. 543, all P 〈0.05）, and the specificity of PET/CT was also higher than that of CT（53.8% （7/13） ; X^2 = 4. 248, P 〈 0.05 ）. The accuracy of PET/CT imaging was higher than that of MRI （ 80.6% （ 54/67 ） ; X^2 = 5. 457, P 〈 0.05 ）. Conclusion is F-FDG PET/CT imaging has high efficaeies and advantages in detection of single spinal metastasis, and it could be considered as a useful diagnostic method when MR/imaging findings are equivocal.
出处
《中华核医学与分子影像杂志》
CSCD
北大核心
2013年第3期179-183,共5页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
天津市应用基础及前沿技术研究计划（08JCZDJC23700）
