摘要
目的探讨血清半胱氨酸蛋白酶抑制剂C(Cys C)在重度子痫前期诊断中的临床意义。方法采集进行围产期保键检查的797例不同孕期的正常孕妇(正常妊娠组)、95例重度子痫前期患者和216名健康体检未孕妇女(正常未孕组)的血清样本,测定其血清Cys C和肌酐(Cr)浓度,采用受试者工作特征(ROC)曲线评价Cys C和Cr对重度子痫前期的诊断价值。结果与正常未孕组相比,孕妇血清Cys C浓度从妊娠中期开始升高(P<0.05),28周以后升高更为明显(P<0.01);与相同孕期的正常妊娠组比较,早发型及晚发型重度子痫前期孕妇血清Cys C均升高(P<0.01),早发型重度子痫升高更为明显;而Cr在早发型和晚发型组仅轻度升高(P>0.05)。Cys C诊断重度子痫前期的ROC曲线下面积(AUC)为0.96。结论血清Cys C能反映孕妇肾脏受损的实际情况,对诊断重度子痫前期有较高的价值。
Objective To investigate the clinical significance of serum cystatin C （Cys C） in the diagnosis of severe preeclampsia. Methods The serum samples were collected from 797 normal pregnant women in the different stages of gestation following perinatal healthy examination （ normal pregnant group ）, 95 pregnant women with severe preeclampsia and 216 healthy non-pregnant women（ healthy non-pregnant group）. The serum Cys C and creatinine （Cr） were measured, and the clinical significance of serum Cys C and Cr in the diagnosis of severe preeclampsia was analyzed by receiver operating characteristic （ROC） curve. Results The serum levels of Cys C elevated from middle-trimester （P 〈0.05）, and increased significantly after 28 weeks＇ gestation compared to healthy non-pregnant group（P 〈0.01 ）. Compared to normal pregnant group in the same gestational period, all serum levels of Cys C increased in early onset and late onset of severe preeclampsia（P 〈 0.01 ）. For the early onset of severe preeclampsia, serum level of Cys C was significantly higher than that for the late onset of severe preeclampsia. However, the levels of Cr increased slightly in the early and late onsets of severe preeclampsia（ P 〉 0.05 ）. ROC analysis on the levels of Cys C showed that an area under the ROC curve（AUC） was 0.96. Conclusions The serum level of Cys C reflects really the renal damage of pregnant women for severe preeclampsia, and it has a high diagnosis significance.
出处
《检验医学》
CAS
2013年第6期471-474,共4页
Laboratory Medicine
