摘要
目的比较子痫前期(PE)与妊娠合并慢性肾脏病孕妇的血清同型半胱氨酸(Hcy)、β2微球蛋白及铁蛋白水平的差异及其与分娩孕周的相关性。方法收集2017年2月至2018年2月于汉中市中心医院产科住院的孕妇共136例,其中PE孕妇(PE组) 53例,妊娠合并慢性肾脏病孕妇(肾脏病组) 39例,正常孕妇(对照组) 44例,分别检测并比较三组孕妇血清中Hcy、β2微球蛋白及铁蛋白的水平,并分析PE与妊娠合并肾脏病孕妇血清Hcy、β2微球蛋白及铁蛋白水平与分娩孕周的相关性。结果 (1)三组孕妇的血清Hcy、β2微球蛋白、铁蛋白水平比较:肾脏病组孕妇的血清Hcy水平明显高于PE组及对照组[(8.85±1.98)μmol/L vs (6.21±1.31)μmol/L,(4.21±0.98)μmol/L],血清β2微球蛋白水平显著高于PE组及对照组[(4.2±2.3) mg/L vs (2.9±0.8) mg/L,(1.7±0.3) mg/L],血清铁蛋白水平显著低于PE组及对照组[(3.0±0.8) g/L vs (3.7±1.1) g/L,(3.6±0.6) g/L],差异均有显著统计学意义(P<0.01);(2) PE组孕妇血清Hcy、β2微球蛋白及铁蛋白水平与分娩孕周的相关性:PE组分娩孕周与Hcy水平无相关性(P>0.05),与β2微球蛋白水平呈负相关(r=-0.412,P=0.031),与铁蛋白水平正相关(r=0.368,P=0.030);(3)肾脏病组孕妇血清Hcy、β2微球蛋白及铁蛋白水平与分娩孕周的相关性:肾脏病组孕妇分娩孕周与Hcy及β2微球蛋白水平呈负相关(Hcy:r=-0.575,P<0.01;β2微球蛋白:r=-0.602,P<0.01),与铁蛋白水平呈明显正相关(r=0.287,P=0.098)。结论 PE与妊娠合并慢性肾脏病孕妇血清Hcy、β2微球蛋白、铁蛋白的水平存在明显差异,且与分娩孕周相关性不一致,可为PE与妊娠合并慢性肾脏病的诊断提供参考。
Objective To observe the difference of serum homocysteine(Hcy),β2-microglobulin, and ferritin in pre-eclampsia(PE) and pregnancies complicated with chronic kidney disease. Methods A total of 136 cases of pregnant woman delivered in Hanzhong Central Hospital from February 2017 to February 2018 were recruited in this study,including 53 cases of pregnancies with PE(PE group), 39 cases of pregnancies with chronic kidney disease(chronic kidney disease group), and 44 cases of normal pregnancies with normal blood pressure and proteinuria without any complication(control group). Serum homocysteine,β2-microglobulin, and ferritin levels were detected. Correlation tests were conducted between these indicators and delivery weeks. Results(1) Comparison of serum homocysteine,β2-microglobulin and ferritin levels in three groups: serum homocysteine level in chronic kidney disease group was(8.85±1.98)μmol/L, significantly higher than(6.21±1.31)μmol/L in PE group and(4.21±0.98)μmol/L in control group(P<0.01);serum β2-microglobulin in chronic kidney disease group was(4.2±2.3) mg/L, significantly higher than(2.9±0.8) mg/L in PE group and(1.7±0.3)mg/L in control group(P<0.01);serum ferritin in chronic kidney disease group was(3.0±0.8) g/L, significantly lower than(3.7±1.1) g/L in PE group and(3.6±0.6) g/L in control group(P<0.01).(2) The correlation between serum homocysteine,β2-microglobulin, ferritin and delivery weeks in PE group: delivery weeks were not correlated with serum homocysteine(P>0.05), but was negatively correlated with β2-microglobulin(r=-0.412, P=0.031) and positively correlated with ferritin(r=0.368, P=0.030).(3) The correlation between serum homocysteine,β2-microglobulin, ferritin and delivery weeks in chronic kidney disease group: delivery weeks were negatively correlated with serum homocysteine,β2-microglobulin(homocysteine: r=-0.575,β2-microglobulin:r=-0.602, both P<0.01), and positively correlated with ferritin(r=0.287, P=0.098). Conclusion The serum levels of homocysteine,β2-microglobulin
作者
袁媛
吴曼莉
赵敏
YUAN Yuan;WU Man-li;ZHAO Min(Department of Obstetrics, Hanzhong Central Hospital, Hanzhong 723000, Shaanxi, CHINA)
出处
《海南医学》
CAS
2019年第7期832-835,共4页
Hainan Medical Journal
