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PPARγ及上皮-间质转化与肿瘤的关系

Peroxisome proliferator-activated receptor gamma and epithelial-mesenchymal transition in cancer
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摘要 肿瘤发生上皮-间质转化(EMT)后侵袭和转移能力明显增强,是肿瘤患者治疗失败的原因之一。过氧化物酶增殖激活受体γ(PPARγ)是EMT的重要调节因子。研究提示,PPARγ激活后能通过调节E-钙黏蛋白、Smad复合体、机体微环境等影响肿瘤EMT的发生发展。因此,深人研究PPARl及EMT与肿瘤的关系有望为肿瘤治疗提供新的方向。 Epithelial-mesenchymal transition (EMT) of cancer can enhance the abilities of invasion and metastasis of cancer cells, which is one of the reasons for treatment failure. Peroxisome proliferator-activa- ted receptor gamma (PPARγ) is an important regulatory factor in EMT of cancer cells. Recent researches show that activation of PPARγ plays a role in the occurrence and development of EMT by regulating the E-cadherin, Smad complex and body microenvironment. Therefore, in-depth research for the relationship among PPARγ, EMT and cancer is expected to provide a new direction for tumor treatment.
作者 高超 冯向营
出处 《国际肿瘤学杂志》 CAS 2013年第6期425-428,共4页 Journal of International Oncology
关键词 PPARΓ 肿瘤 SMAD蛋白质类 E-钙黏蛋白 PPAR gamma Neoplasms Smad protein E-cadherin
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