摘要
肿瘤发生上皮-间质转化(EMT)后侵袭和转移能力明显增强,是肿瘤患者治疗失败的原因之一。过氧化物酶增殖激活受体γ(PPARγ)是EMT的重要调节因子。研究提示,PPARγ激活后能通过调节E-钙黏蛋白、Smad复合体、机体微环境等影响肿瘤EMT的发生发展。因此,深人研究PPARl及EMT与肿瘤的关系有望为肿瘤治疗提供新的方向。
Epithelial-mesenchymal transition (EMT) of cancer can enhance the abilities of invasion and metastasis of cancer cells, which is one of the reasons for treatment failure. Peroxisome proliferator-activa- ted receptor gamma (PPARγ) is an important regulatory factor in EMT of cancer cells. Recent researches show that activation of PPARγ plays a role in the occurrence and development of EMT by regulating the E-cadherin, Smad complex and body microenvironment. Therefore, in-depth research for the relationship among PPARγ, EMT and cancer is expected to provide a new direction for tumor treatment.
出处
《国际肿瘤学杂志》
CAS
2013年第6期425-428,共4页
Journal of International Oncology