摘要
趋化因子在细胞的转化和黏附中发挥重要作用。现已证实CXCR7与趋化因子CXCLl2和CXCLll有高亲和力，而且趋化因子受体CXCR7激活后，可通过调节细胞外基质（ECM）、上皮-间质转化（EMT）及其他信号转导通路等影响肿瘤的侵袭和转移。因此，深入研究趋化因子受体CXCR7与肿瘤侵袭和转移的分子机制有望为肿瘤治疗提供更有效的理论基础。
Chemokines are major regulators of cell transformation and adhesion. Recent study has dem- onstrated that CXCR7 can bind to CXCL11 and CXCL12 with high affinity, and the activated CXCR7 may influ- ence tumor invasion and metastasis by regulating extracellular matrix （ECM） and epithelial-mesenchymal tran- sition （EMT） and other signal transduction pathways. Therefore, in-depth study of the molecular mechanisms of CXCR7 in tumor invasion and metastasis may provide a more effective theoretical basis for tumor treatment.
出处
《国际肿瘤学杂志》
CAS
2013年第10期742-744,共3页
Journal of International Oncology
关键词
CXCR7
肿瘤
细胞外基质
上皮-间质转化
CXCR7
Neoplasms
Extracellular matrix
Epithelial-mesenchymal transition
