摘要
目的 评价牙周炎患者局部应用米诺四环素对其龈沟液中胶原酶活性的影响及其临床疗效。方法 采用单盲随机对照法 ,选择 31例慢性牙周炎患者 ,分为用药组和对照组 ,每组各 6 0个探诊深度 >5mm且探诊后出血的牙位点。在基线前须完成全口龈上洁治及口腔卫生宣教。检查 :基线时试验牙取龈沟液样本 (测定胶原酶 ) ,记录菌斑指数、探诊深度、附着丧失和探诊出血 ,然后行龈下刮治术 ,用药侧每周放 1次药 ,共 4次 ,对照侧不放药。第 4、7、11周的检查同上。结果 用药组龈沟液中胶原酶水平与其基线、对照组相比明显下降 (P <0 .0 1) ,其他各项临床指标的改善也更为明显。结论 应用米诺四环素软膏作为牙周炎基础治疗的辅助疗法 ,能有效降低龈沟液中胶原酶活性水平 ,从而有效地阻止牙周组织的破坏。
Objective To evaluate the effect of scaling and root planing combined with local application of 2% minocycline hydrochoride ointment(Periocline) on the level of collagenase activity releasing from PMNs in GCF. Methods This was a randomized, single-blinded, split mouth design study. The target sites of 31 patients with moderate to severe periodontitis (PD>5 mm) was randomized by left-side and right-side into one of the two groups (the test group and the control group). Subsequently each patient was scheduled for two appointments for the full-month supra-gingival scaling and oral hygiene instruction. At baseline all patients received subgingival scaling and root planing and were followed by 4-time applications of Periocline with one-week interval for totally four weeks in the test group. All patients were taken GCF for measuring collagenase by the method of Nakashima et al(1996) and were examined based on four parameters, including plaque index, pocket depth, attachment loss and bleeding on probing. Results Four weeks after root planing with 4-time applications of Periocline, all clinical parameters and active collagenase in GCF decreased significantly in the test groups[(593±112)mU/sample vs (311±98)mU/sample , P <0.001]. On the other hand, simple root-planing therapy had limited effect on the active collagenase[(611±123)mU/sample vs (523±127)mU/sample], although all clinical parameters were also reduce significantly. Interestingly, seven weeks later, gingival infla mmation and the active collagenase were reduced more significantly than those after four-week root planing in both groups[Test:(311±98)mU/sample vs (207±57)mU/sample; Control:(523±127)mU/sample vs (345±117)mU/sample, P <0.001]. At eleven week, gingival infla mmation and the level of collagenase activity were rebounded in the control group[(467±108)mU/sample].However, in the test group they were kept in lower level[(213±121)mU/sample]. The level of collagenase activity showed significantly positive correlation with GCF volumes and A
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2000年第5期336-339,共4页
Chinese Journal of Stomatology
