摘要
目的:建立采用抑制型离子色谱法测定复方氯化钠注射液中氯化钠、氯化钾和氯化钙含量的方法。方法:色谱条件为IonPac CS 12A色谱柱(4 mm×250 mm),淋洗液为25 mmol.L-1甲烷磺酸溶液,流量1.0 mL.min-1;抑制器为CSRS 3004 mmself-Regenerating Suppressor;抑制电流90 mA;电导检测器。结果:氯化钠、氯化钾和氯化钙线性范围分别为2.25～225μg.mL-1(r=0.9999)、1.71～171μg.mL-1(r=0.9999)和1.47～147μg.mL-1(r=0.9999),回收率分别为100.8%、101.3%和99.1%。结论:本方法准确、简便,可用于复方氯化钠注射液的质量控制。
Objective：To approach an assay method for determination of sodium chloride, potassium chloride and calcium chloride in Compound Sodium Chloride Injection by IC. Methods： The assay was performed on IonPac CS 12A column（4 mm × 250 mm）with 25 mmol·L-1 methanesulfonic acid solution as eluting solution. The flow rate was 1.0 mL ·rain-1. The Suppressor was CSRS 300 4mm self-Regenerating Suppressor. Suppress current was 90 mA. Electrolytic conductivity detector. Results： The linear ranges of sodium chloride, potassium chloride and calcium chloride were 2. 25-225 μg · mL-1 （ r = 0. 9999 ）, 1.71-171 μg · mL-1 （ r = 0. 9999 ） and 1.47-147 μg · mL - 1 , （ r = 0. 9999 ） respectively. The average recoveries （ n = 9 ） of sodium chloride, potassium chloride and calcium chloride were 100. 8%, 101.3% and 99. 1%, respectively. Conclusions：The method is proved to be accurate and convenient, and provided a reliable way for evaluating the quality of Compound Sodium Chloride Injection.
出处
《中国药品标准》
CAS
2013年第2期110-112,共3页
Drug Standards of China
关键词
离子色谱法
复方氯化钠注射液
氯化钠
氯化钾
氯化钙
IC
Compound Sodium Chloride Injection
sodium chloride
potassium chloride
calcium chloride
