摘要
目的:分析血清神经特异性烯醇化酶(NSE)和血清钙水平与新生儿缺氧缺血性脑病(HIE)的临床相关性,探讨新生儿HIE早期诊断的有效参考指标。方法:选择同期HIE新生儿62例,根据临床表现分为轻度组(n=24例)、中度组(n=20例)和重度组(n=18例),分析以上新生儿在出生第1 d、第3 d和第5 d的血清NSE和血清钙水平的动态改变与病变严重程度间的临床相关性。结果:出生第1 d血清NSE水平与病变严重程度间呈正相关性(P<0.05),血清钙水平与病变严重程度间呈负相关性(P<0.05),不同严重程度HIE新生儿间血清NSE和血清钙水平差异具有统计学意义(P<0.01,P<0.05);出生第1d与第3d、第5d的血清NSE和血清钙水平比较,差异具有统计学意义(P<0.01,P<0.05)。结论:血清NSE和血清钙水平与新生儿HIE密切相关,可反映新生儿HIE的严重程度与发展情况,两者是反映新生儿HIE诊治的有效参考指标。
Objective： To analyze the clinical correlation of serum NSE and serum calcium levels with neonatal hypoxic ischemic encephalopathy and to research the effective indicator for the early diagnosis of neonatal HIE. Methods： 62 HIE neonatal were collected, and were divided into mild group, moderate group and severe group, according to the clinical manifestations, and the clinical correlation of dynamic changes of serum NSE and serum calcium levels with the disease severity were analyzed. Results： Serum NSE was respectively positively correlated （P〈0.05） with the disease severity, serum calcium was negatively correlated（P〈0.05） with the disease severity; there was a （highly） significant difference （P 〈0.01, P 〈0.05） in the different severity of HIE neonatal; there was a （highly） significant difference （P〈0.01, P〈0.05） in the different treatment time. Conclusion： The serum NSE and serum calcium levels were closely related to the neonatal hypoxic ischemic encephalopathy, and could be used as the valid indicator in monitoring the neonatal hypoxic ischemic encephalopathy.
出处
《现代生物医学进展》
CAS
2013年第8期1539-1541,1585,共4页
Progress in Modern Biomedicine
关键词
血清NSE
血清钙
新生儿
缺氧缺血性脑病
临床相关性
Serum NSE
Serum calcium
Neonatal
Hypoxic ischemic encephalopathy
Clinical relevance
