期刊文献+

急性脑梗死患者血清血管内皮生长因子的变化 被引量:2

下载PDF
导出
摘要 目的:探讨急性脑梗死(acute cerebral infarction,ACI)患者血清血管内皮生长因子水平的变化及其临床意义。方法:选择正常对照组134例,ACI组168例,用酶联免疫法(ELISA)测定血清VEGF含量,测定数据进行统计学分析。结果:①两组间血清VEGF含量存在显著差异。②ACI患者不同时间段血清VEGF含量存在显著差异。③血清VEGF与脑梗死部位,体积及缺血缺氧程度呈正相关。结论:VEGF可能共同参与了ACI的病理生理过程并促进ACI的发生、发展。
作者 白嘎丽
出处 《内蒙古医学杂志》 2013年第1期79-81,共3页 Inner Mongolia Medical Journal
  • 相关文献

参考文献14

  • 1李耀辉,杨英.血管内皮生长因子对冠心病的影响[J].疾病监控与控制杂志,20lO,4(6):327-328. 被引量:1
  • 2Yasuhara T, Shingo T, Date I. The potential role of vascular en- dothelial growth factor in the central nervous system[J]. Rev Neu- rosci, 2004, 15(4) : 293 - 307. 被引量:1
  • 3Ziemer LLS, Koch CJ, Maity A, et al. Hypoxia and VEGF mRNA expression in human tumors [ J ]. Neoplasia, 2001, 3 ( 6 ) : 500 - 508. 被引量:1
  • 4Zamarron - Sanz C, Ricoy- Galbaldon J, Gude - Sampedro F, et al. Plasma levels of vascular endothelial markers in obstructive sleep apnea[J]. Arch Med Rep 2006, 37(4) : 552 - 555. 被引量:1
  • 5Inoue M , Itoh H , Tanaka T, et al . Oxidized - LDL regulates vascular endothelial growth factor expression in human macrophages and endothe- lial cells through activation of preoxi- some proliferator activated receptor - gamma [ J ]. hrterioscler Thromb Vase Biol, 2001, 21(4) : 560 - 566. 被引量:1
  • 6Valable , Samuel . VEGF - induced BBB permeability is associated withan MMP - 9 activity increased in cerebral ischemia: Both ef- feels decreased by Ang - l[J]. Cereb Blood Flow Metab, 2005, 25 (11):1 491. 被引量:1
  • 7Bao WL, Lu SD, Wang H, et al. Intravantricular vascular endoth - elial growth factor anti]xxiy increases infaret vohume following transient cerebral isehemia[J]. Chongguo Yao Li Xue Bao, 1999, 20(4):313 - 318. 被引量:1
  • 8SlevinM, Krupinski ], Slowlk A, et al. Serialrneasure - mentor- vascular endothelialgrowth factor and transforminggrowth factor- lin serum ofpatientswith acute ischemicstroke[J ]. Stroke, 2000, 31(8):1 863- 1 870. 被引量:1
  • 9Jin KL, MAO XO, Greenberg DA. Vascular endothelial growth fac -tor direct neuroprotective efeect in vitro ischemia[J]. Proc Natl AcadSci USA, 2000, 97(18) : 10 242 - 10 247. 被引量:1
  • 10Jin KL, Mao XO, Greenberg DA. Vascular endothelial growth factor: Direct neuroprotec'tive effect in in vitro ischemia[ J ]. Proc- Nail Acad Sci USA, 2000, 97:10 242- 10 247. 被引量:1

二级参考文献12

  • 1[1]Ferrara N,Henzel WJ.Pituitary follicular cells secrete a novel heparin-hinding growth factor specific for vagcular endothelial cells.Biochem Biopbys Res Commun,1989,161:851-858 被引量:1
  • 2[2]Vcikkola T,Karkkaincn M,Clacsson-W clsh L,et al.Regulation of angiogenesis via vascular endothelial growth factor receptor Cancer Res,2000,60(2):202 被引量:1
  • 3[3]Nishikawa R,Cheng SY,Nagashima R,et al.Expression of vascular endothelial growth factor in human brain tumors.Acta Neuropat hol(Berl),1998,96:453-462 被引量:1
  • 4[5]Jin KL,MAO XO,Greenberg DA,Vascular endothelial growth factor direct neuroprotective efeect in vitro ischemia.Proc Natl Acad Sei USA,2000,97(18):10242-10247 被引量:1
  • 5[6]Schratzberger P,Schratzberger G,Silver M,et al.Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy.Nat Med,2000,6:405-413 被引量:1
  • 6[7]Hayashi T,Abe K,Itoyama Y.Reduction of iachemic damage by application of vascular endothelial growth factor in rat brain after transient ischemic.J Cereb Blood Flow Metab,1998,18:887-895 被引量:1
  • 7[8]Barleon B,Hanser S,Schollmann C,et al.Differential expression of the two VEGF receptor flt and KDR in placenta and vascular endothelial cells.Cell Biochem,1994;54(1):56 被引量:1
  • 8[9]Sun Y,Jin K,Xie L,et al.VEGF-induced neumprotection,neurogensis,and angiogenesis after focal cerebral ischem ia J.Clin in vest,2003,111(12):1843 被引量:1
  • 9[10]Zhang ZG,Zhang L,Jiang Q,et al.VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain J.Clin Invest,2000,106(7):829-838 被引量:1
  • 10[11]Bao WL,Lu SD,Wang H,et al.Intraventricular vascular endoth elial growth factor antibody increases infarct vohume following transient cerebral isehemia.Chongguo Yao Li Xue Bao,1999,20(4):313-318 被引量:1

共引文献1

同被引文献30

  • 1Ferrara N,Henzel WJ,Pituitaty follicular cells secrete a heparinbinding growth factor specifie for vascular endothelial cells[J].Biochem Biophys Res Commun,1989,161(2):851-858. 被引量:1
  • 2Donald RS,Livingston VD,Lawrence FB,et al.Vaseular permeability factor in tumorbiology[J].Cancer Metastassis Rev,1993,12(2):303-307. 被引量:1
  • 3Koyama J.Miyake S,Sasayama T,et al.The novel VEGF receptor antagonist,VGAI 155,reduces edema,decreases infarct and improves neurological function after stroke in rats[J].Kobe J Med Sci,2010,56(1):1-11. 被引量:1
  • 4Gutierez-Fernandez M.Rodriguez-Frutos B.AlvarezGrech J.Functional recovery after hematic adminstration of allogenic mesenchymal stem cells in acute ischemic stroke in rats[J].Neuros cience,2011,175(4):394-405. 被引量:1
  • 5Patruno R.Arpaia N,Gadaleta CD,et al.VEGF concentration from plasmactivated platelets rich correlates with microvascular density and grading in canine mast cell tumour spontaneous model[J].J Cell Mol Med,2009,13(3):555-561. 被引量:1
  • 6Sun Y,Jin K,Lin X,et al.VEGF-induced neuroprotection,neurogenesis,and angiogenesis after focal cerebral ischemia[J].J Clin Invest,2003,111(12):1843-1847. 被引量:1
  • 7史福平,邸卫英,王惠凌,等.血清VEGF和TNF-α在急性脑梗死患者中的动态变化研究[J].中国急救医学,2013,33(8)增刊:4-6. 被引量:2
  • 8Peng Hu Y,Feng N.L-3-n-butyl-phthalide allevares hydrogen peroxide-induced apoptosis by PKG pathway in human nearoblastoma SK-N-SH cells[J].Nattnyn Schniedebergs Arch Pharnael,2011,383(1):91-99. 被引量:1
  • 9Li J,Li Y,Ogle M,et al.DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway[J].Brain Res,2010,1359(2):216-226. 被引量:1
  • 10俞鸣.急性脑梗死患者血清血管内皮生长因子和基质金属蛋白酶-9水平的动态变化及其意义[J].中国全科医学,2010,13(18):1983-1985. 被引量:10

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部