摘要
目的探讨结节性硬化症合并癫痫患儿的临床特征。方法回顾性分析33例结节性硬化症合并癫痫患儿的临床资料。结果33例患儿中，不同癫痫发病年龄、发作形式及有无家族史、热惊史患儿服药数量比较差异无统计学意义（P〉0．05）。出生史及发育情况不同的患儿服药数量比较差异有统计学意义（P〈0．05）。癫痫首发年龄与初诊年龄之间呈正相关（P=0．015），癫痫诱因发作与热惊史之间呈正相关（P=0．021），患儿皮肤损害与发育落后无关联性（P=0．409）。结论出生异常或发育情况异常患儿可能需要联合抗癫痫药物治疗。癫痫首发年龄越早，越益于早期就诊。有热惊史诱发因素患儿更易引起抽搐发作。皮肤损害患儿可不合并发育落后。
Objective To investigate the clinical features of children with tuberous sclerosis complex complicated with epilepsy. Methods The clinical data of 33 children tuberous sclerosis com- plex complicated with epilepsy were analyzed retrospectively. Results Thirty-three cases of children had different epilepsy onset age, form of attack, family history and febrile seizures history, differences in children with medication quantity was not statistically significant （ P 〉 0.05 ）. For children with different birth history and developmental condition, the difference of medication quantity was statistically significant （ P 〈 0. 05 ）. The age of first seizure onset was positively correlated with newly diagnosed age （ P = 0. 015）, there was positive correlation between seizures incentives and febrile seizures （P = 0. 021 ）. Children skin lesions did not correlated with developmental retardation （P = 0. 409 ）. Conclusions Children with birth abnormalities or abnormal development of the situation may need a joint anti-epileptic medication. The epileptic starting earlier the age, the more benefit from early treatment. History of febrile seizures was children more likely to cause epilepsy. Children with the skin lesions may have normal intelligence.
出处
《中国实用医刊》
2013年第7期56-58,共3页
Chinese Journal of Practical Medicine
关键词
结节性硬化症
癫痫
儿童
Tuberous sclerosis com plex
Epilepsy
Children
