摘要
目的观察急性脑梗死(ACI)患者血小板膜糖蛋白(GP)、急性生理学及慢性健康状况评分(APACHEⅡ评分)和美国国立卫生研究院卒中量表评分(NIHSS评分)的变化及与预后的相关性。方法选择ACI患者68例(ACI组),另选健康体检者48例(对照组);又根据转归将ACI组分为生存组和死亡组两个亚组;测定各组血GP水平、APACHEⅡ评分及NIHSS评分。结果与对照组比较,ACI组患者GP均明显升高,差异有统计学意义(P<0.05);与生存组比较,死亡组APACHEⅡ评分、NIHSS评分及GP水平均明显升高,差异有统计学意义(P<0.05);ACI患者GP水平与NIHSS评分及APACHEⅡ评分,NIHSS评分与APACHEⅡ评分均呈明显正相关(均P<0.05);多因素logistic回归分析显示:APACHEⅡ评分、NIHSS评分、GP与ACI患者的死亡明显相关。结论GP与ACI患者病情严重程度呈正相关,血小板活化状态对于评估ACI患者病情轻重以及判断预后有着重要的意义。
Objective To investigate of the prognostic significance of platelet glycoprotein （ GP）, Acute Physiol- ogy and Chronic Health EvaluationⅡ （APACHE Ⅱ ） and acute Institute of Health Stroke Scale （NIHSS） in acute cere- bral infarction （ACI）. Methods 68 patients with ACI and 48 health people were included in ACI group and control group, respectively. The ACI group was further divided into two subgroups, survival subgroup and non - survival sub- group, according to outcomes. GP, APACHE Ⅱ and NIHSS were assessed. Results The levels of GP, APACHE Ⅱand NIHSS in ACI group were significantly higher than those in control group （P 〈 0.05） ; Furthermore, they were significant- ly lower in survival subgroup than in non - survival subgroup （ P 〈 0. 05 ）. The GP was significantly positive correlated with APACHE Ⅱ and NIHSS in patients with ACI. According to logistic regression analysis, GP, APACHE Ⅱand NIH- SS were proved potential prognostic factors for patients with ACI. Conclusion GP, APACHEⅡ and NIHSS can be im- portant prognostic indexes for ACI.
出处
《广东医学》
CAS
CSCD
北大核心
2013年第5期704-706,共3页
Guangdong Medical Journal
基金
湖南省自然科学基金资助项目(编号:08JJ3036)
关键词
血小板活化状态
急性脑梗死
预后
platelet activation
acute cerebral infarction
prognosis
