摘要
目的比较观察氯吡格雷和阿司匹林治疗急性脑梗死的疗效及安全性。方法 120例急性脑梗死患者随机分为氯吡格雷组(60例)和阿司匹林组(60例),分别服用氯吡格雷(50mg/d)及肠溶阿司匹林(100mg/d),治疗同时,两组均给予相同的抗高血压、降颅压、营养神经及对症支持治疗,疗程为14d,测定治疗前后血浆高敏C反应蛋白(hs-CRP)和血小板聚集率的变化,并评定临床疗效和观察不良反应。结果氯吡格雷组与阿司匹林组对hs-CRP和血小板聚集率均有明确的抑制作用(P<0.05),但氯吡格雷组优于阿司匹林组(P<0.05);同时氯吡格雷组的临床有效率明显高于阿司匹林组,而阿司匹林组出现不良反应的发生率高于氯吡格雷组,但无严重事件发生。结论服用氯吡格雷治疗急性脑梗死较阿司匹林治疗的临床疗效确切,且较安全可靠,值得临床应用。
Objective To compare the efficacy and safety of clopidogrel and aspirin on treatment of acute cerebral infarction.Methods 120 cases of acute cerebral infarction were randomly divided into clopidogrel group（60 cases） and aspirin group（60 cases）,were taking clopidogrel （50mg/d）,and enteric-coated aspirin （100mg/d,） on the same time,two groups were given the same anti-high blood pressure,reducing the intracranial pressure,nutrition nerve and symptomatic supportive care,measuring before and after treatment of plasma high-sensitivity C-reactive protein （hs-CRP） and platelet aggregation rate of change after treating 14d,assessing the clinical efficacy and observing adverse reaction.Results The inhibition of hs-CRP and platelet aggregation in clopidogrel group and the aspirin group were clearly,but the clopidogrel group was better than aspirin group,The same time,clinical efficacy of clopidogrel group was significantly higher than aspirin group,while the incidence of adverse reaction in aspirin group was higher than the clopidogrel group,but no serious incidents.Conclusion Taking clopidogrel has clinical curative effect in the treatment of acute cerebral infarction compared with aspirin treatment,and relatively safe,it is worth clinical application.
出处
《实用心脑肺血管病杂志》
2010年第9期1224-1226,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
氯吡格雷
阿司匹林
脑梗死
Clopidogrel
Aspirin
Cerebral
Infarction
