摘要
目的探讨执行控制过程中健康人大脑前扣带回（ACC）与背外侧额前皮质（DLPFC）之间的功能连接及其与行为学表现之间的关系。方法2011年1至5月25名17～20岁的健康志愿者在青岛大学医学院附属医院放射科进行3．0T功能磁共振扫描，采用注意网络测试（ANT）作为试验范式，计算ACC和DLPFC之间的功能连接，并与ANT的行为学得分做相关分析。结果在执行控制过程中，背侧ACC（dACC）与两侧的DLPFC之间存在显著的功能连接，其中左侧的dACC和DLPFC之间的功能连接系数与执行控制的行为学得分存在显著负相关（r=-0．63；P〈0．01）。结论ACC与DLPFC之间存在功能连接，并对注意的执行控制功能存在有利的影响，这有助于我们理解注意功能中相关脑区的功能整合作用。
Objective To explore the presence of functional connectivity between anterior cingulate cortex （ ACC ） and dorsolateral prefrontal cortex （DLPFC） during the manipulation of attentional network test （ANT） and its relationship with behavioral performance. Methods Functional magnetic resonance imaging was performed on 25 healthy subjects aged 17 - 20 years. And ANT was used as a paradigm. Functional connectivity between ACC-DLPFC was tested and correlation analysis conducted between functional connectivity coefficients and behavioral scores of ANT. Results Significant functional connectivity between the dorsal ACC （dACC） with bilateral DLPFC was found. Furthermore, event-related functional connectivity coefficients between left dACC and left DLPFC were negatively associated with the behavioral scores of executive control （r = - 0. 63 ; P 〈 0. 01 ）. Conclusion Our findings provide new evidence that ACC and DLPFC are functionally connected and such functional connectivity has advantageous influence on executive control function of attention so as to contribute to our understanding of the integrated role of these brain regions in attentional network.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2013年第13期995-998,共4页
National Medical Journal of China
基金
国家自然科学基金（30871305）
关键词
磁共振成像
大脑皮质
扣带回
Magnetic resonance imaging
Cerebral cortex
Gyrus cinguli
