摘要
目的探讨利培酮对军人精神分裂症患者神经行为功能的影响。方法 42例军人精神分裂症患者（患者组）接受利培酮（3~8 mg/d）治疗,于治疗前、治疗12周和治疗24周分别评定神经行为核心测试组合（NCTB）,及阴性与阳性症状量表（PANSS）,并与42例健康人（对照组）进行比较。结果治疗12周时,患者组PANSS总分、平均反应时、最快反应时均较治疗前显著下降（P〈0.05）;手工敏捷度、数字译码、正确打点数均较治疗前显著提高（P〈0.05）;其余NCTB指标变化差异无统计学意义（P〉0.05）。治疗后24周与治疗后12周比较,NCTB各项指标变化差异无统计学意义（P〉0.05）;治疗24周时,患者组各项NCTB指标神经行为与对照组比较,差异无统计学意义（P〉0.05）。结论利培酮能够较好的改善军人精神分裂症患者的神经行为功能。
Objective To explore the effects of risperidone on neurobehavioral function in military schizophrenic patients.Methods A total of 42 military schizophrenic patients and 42 normal controls were assessed with WHO-NCTB and PANSS at baseline. The patients were reassessed at 12 weeks and 24 weeks after risperidone treatment. Scores of WHO-NCTB and PANSS of patients were compared with those of controls. Results At 12 weeks after treatment,the total score of PANSS,average reaction time and fastest reaction time of patients were significantly decreased compared to baseline（ P 〈0. 05）,while Santa Anna manual dexterity test,digit symbol test and correct tapping dots were increased significantly（ P〈 0. 05）. At 24 weeks after treatment,there was no significant changes observed on average reaction time,fastest reaction time,Santa Anna manual dexterity test,digit symbol test,and correct tapping dots compared with 12 weeks（ P 〉0. 05）. There was no significant difference in NCTB between case group and control group（ P 〉0. 05） at 24 weeks after treatment. Conclusion The neurobehavioral function could be improved after risperidone treatment in military schizophrenic patients.
出处
《临床军医杂志》
CAS
2015年第6期603-606,共4页
Clinical Journal of Medical Officers
基金
南京军区医学科技创新课题(08MB126)
