摘要
随着对肿瘤表观遗传学的深入研究,发现DNA甲基化异常在慢性粒单核细胞白血病(CMML)的发生和转化中起着重要作用。地西他滨是一种去甲基化药物,研究发现,其具有抑制甲基化转移酶的作用,在骨髓增生异常综合征(MDS)和白血病的治疗中已取得较好的疗效,地西他滨的表观遗传学治疗在CMML治疗中的地位也日益重要。
With the further research on the tumor epigenetics,we discover that DNA methylation plays an important role in the occurrence and transformation of chronic myelomonocytic leukemia（CMML）.Decitabine is a kind of hypomethylation drug,it can inhibit the methyltransferase with good curative effect in the treatment for myelodysplastic syndromes（MDS）and leukemia.Epigenetics treatment of CMML with decitabine is becoming increasingly important.
出处
《实用药物与临床》
CAS
2013年第3期248-249,共2页
Practical Pharmacy and Clinical Remedies
