摘要
生物医学光子学的发展,总是伴随并促进着光子学新技术的发展。光学生物成像技术在癌症肿瘤诊断上有着巨大应用,尤其是具有优良发光特性的稀土离子掺杂的上转换发光纳米颗粒与光学生物成像技术的结合进一步发展了生物光子学在这一领域的应用。鉴于近几年很多人对上转换发光纳米粒子的大量研究,本文对其进行了系统的阐述,综述了稀土上转换发光纳米粒子的光学特异性、发光原理及其在光学成像中不可替代的优势;描述了上转换纳米粒子的化学组成,介绍了几种基本的合成方法,重点说明了水热合成法和热分解法,并从材料和光学两方面分析了生物应用的效率优化;总结了目前上转换材料在生物光子学中的几大应用,着重介绍了生物传感、细胞成像、动物成像、漫射光层析成像、光动力治疗、多模式成像六个方面的应用。本文在最后也对今后的研究进行了展望。
With the appearance of interdiscipline, the development of biomedical technology has been advanced by the novel technologies from other disciplines. Optical bioimaging technology is a powerful tool for the diagnosis of cancer tumors. The rare-earth-ion doped upconversion nanoparticles （UCNPs） combined with optical bioimaging technique has generated a lot of interest in this field due to its unique optical properties. Based on a large number of investigations on the progress of UCNPs in recent years, in this paper we comprehensively reviewed many aspects of UCNPs, including the principle of luminescence, the optical uniqueness of UCNPs and the composite of nanoparticles. What＇ s more, several typical synthetic methods were also introduced with hydro（solvo） thermal method and thermal decomposition method were highlighted. And we also summarized several applications of UCNPs in biomedical optics, such as biological sensing, cell imaging, animal imaging, diffuse optical imaging and photodynamic therapy.
出处
《激光生物学报》
CAS
CSCD
2013年第1期13-25,共13页
Acta Laser Biology Sinica
基金
华南师范大学青年教师科研培育基金项目(2012KJ017)
