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新辅助化疗联合保乳术治疗Ⅱ、Ⅲ期乳腺癌的疗效 被引量:48

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摘要 目的评价Ⅱ、Ⅲ期乳腺癌经新辅助化疗后行保乳手术的疗效和美容效果,探讨Ⅱ、Ⅲ期乳腺癌保乳综合治疗的可行性。方法回顾性分析56例经粗针穿刺活检确诊为乳腺癌的女性患者,TNM分期为Ⅱ期26例,Ⅲ期30例。化疗方案为TAC方案,每3周重复,化疗4~6个周期。对完全缓解(CR)、部分缓解(PR)的患者行肿瘤局部广泛切除及腋窝淋巴结清扫术,术后常规辅以全乳放疗、化疗及内分泌治疗。对新辅助化疗疗效、术后乳房美容效果进行评估,并随访统计局部复发及远处转移率、无进展生存期。结果新辅助化疗总有效率71.4%(40/56),36例患者成功实施保乳手术,保乳率64.3%(36/56)。保乳综合治疗患者随访42~96个月,中位随访67.2个月。保乳术后美容效果评价优秀加良好率63.9%(23/36),局部复发4例,远处转移4例,中位无进展生存期64.3个月。结论Ⅱ、Ⅲ期乳腺癌经新辅助化疗缩小、降期后,在无禁忌证的前提下,实施保乳手术后疗效可靠,生存期无明显下降。
出处 《广东医学》 CAS CSCD 北大核心 2013年第4期611-613,共3页 Guangdong Medical Journal
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参考文献8

  • 1沈镇宙,邵志敏主编..乳腺肿瘤学[M].上海:上海科学技术出版社,2005:462.
  • 2BONADONNA G, VEMNESI U, BRAMBILLI C, et al. Primary chemotherapy to avoidmastectomy in tumors with diameters or three centimeters of more [ J]. J Natl Cancer Inst, 1990, 82 (19) : 1539 - 1545. 被引量:1
  • 3FISHER B, BROWN A, MAMOUNAS E, et al. Effect of preoper-ative chemotherapy on local - regional disease in women with oper- able breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B - 18[J]. J Clin Oncol, 1997, 15(7): 2483 - 2493. 被引量:1
  • 4VAN DER HAGE J A, VAN DE VELDE C J, JULIEN J P, et al. Preoperative chemotherapy in primary operable breast cancer: re- suits from the European Organization for Researeh and Treatment of Cancer trial 10902[ J]. J Clin Oneol, 2001, 19(22) : 4224 - 4237. 被引量:1
  • 5张斌,王坤.新辅助化疗后的保乳手术:MD Anderson癌症中心的经验[J].循证医学,2007,7(3):135-137. 被引量:2
  • 6VYZULA R, DUSEK L, ZALOUDIK J, et al. Breast cancer and neoadjuvant therapy: any predictive marker? [ J ]. Neoplasma, 2004, 51(6):471 -480. 被引量:1
  • 7TOZAKI M, KOBAYASHI T, UNO S, et al. Breast -conserving surgery after chemotherapy: value of MDCT for determining tumor distribution and shrinkage pattern [ J ]. A JR Am J Roentgenol, 2006, 186(2) : 431 -439. 被引量:1
  • 8SPEAR S L, PELLETIERE C V, WOLFE A J, et al. Experience with reduction mammaplast combined with breast conserving thera- py in the treatment of breast cancer [ J ]. Plast Rsconstr Surg, 2003, 111(3): 1102-1109. 被引量:1

二级参考文献5

  • 1张斌,张强.可手术乳腺癌的新辅助全身治疗[J].中华肿瘤杂志,2007,29(3):161-165. 被引量:20
  • 2Rouzier R,Extra JM,Carton M,et al.Primary chemotherapy for operable breast cancer:Incidence and prognostic significance of ipsilateral breast tumor recurrence after breast-conserving surgery[J].J Clin Oncol,2001,19:3828-3835. 被引量:1
  • 3Fisher B,Bryant J,Wolmark N,et al.Effect of preoperative chemotherapy on the outcome of women with operable breast cancer[J].J Clin Oncol,1998,16:2672-2685. 被引量:1
  • 4Bonadonna G,Valagussa P,Brambila C,et al.Primary chemotherapy in operable breast cancer:Eight-year experience at the Milan Cancer Institute[J].J Clin Oncol,1998,16:93-100. 被引量:1
  • 5Bear HD,Anderson S,Smith RE,et al.Sequential preoperative or postoperative Doxorubicin plus Cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27[J].J Clin Oncol,2006,24:2019-2027. 被引量:1

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