摘要
目的:了解我院抗菌药物临床应用及细菌耐药情况,为合理使用抗生素提供参考。方法:调取我院2011年抗菌药物出库数据,采取限定日剂量(DDD)法分析抗菌药物使用情况;利用2011年细菌耐药监测数据,分析病原菌对抗菌药物的耐药情况。结果:第三代头孢菌素类抗菌药物使用频度最高,同期临床分离的病原菌主要有大肠埃希菌、金黄色葡萄球菌、表皮葡萄球菌、肺炎克雷伯菌等,其中以大肠埃希菌检出最多。产超广谱β-内酰胺酶(ESBLs)大肠埃希菌、产ESBLs肺炎克雷伯菌对第三代头孢菌素100%耐药,1例产ESBLs肺炎克雷伯菌菌株对亚胺培南耐药。结论:我院第三代头孢菌素类抗菌药物存在不合理使用情况,且细菌耐药情况较严重。第三代头孢菌素的广泛应用是导致产超广谱β-内酰胺酶菌株出现及传播的主要原因,应引起高度重视。
Objective： To understand the use of antibacterials and antibiotic resistance in our hospital, and to provide reference for clinical rational drug use. Methods： The use of antibacterial drugs in our hospital was analyzed by defined daily dose（DDD） method through 20l 1 antibacterial drug sales data. The antibiotic resistance rate of pathogenic bacteria was analyzed through bacterial resistance surveillance data. Results： The use of third-generation cephalosporins was the most frequent. In 2011, the main isolated pathogens were Escherichia coli, Staphylococcus aureus, Staphylococcus aureus and Klebsiella pneumoniae. And the most of detection were Eseherichia coli. Producing ESBLs （ extended-spectrum β^-lactamases ） of Escherichia coli and producing ESBLs of Klebsiella pneumoniae were 100% resistant to third-generation cephalosporins. There was one case that producing ESBLs of Klebsiella pneumoniae was resistant to imipenem. Conclusions： In this hospital third-generation cephalosporins were not reasonable used, and the situation of antibiotic resistance was serious. Irrational use of third-generation cephalosporin is the main factor that causes extended-spectrum β-lactamases enzyme strains appeared and spread. This problem should be drawn great attention.
出处
《儿科药学杂志》
CAS
2013年第3期35-38,共4页
Journal of Pediatric Pharmacy
关键词
抗菌药物
用药频度
耐药性
Antibacterial drugs
DDDs
Drug resistance
