摘要
目的 探讨某院大肠埃希菌临床分离株对临床常用抗菌药物的耐药性变迁。方法 采用回顾性调查的方法,对2 0 0 2 - 2 0 0 4年分离的大肠埃希菌及其药物敏感(药敏)试验结果进行统计分析。结果 3年间共分离出大肠埃希菌5 0 7株,检出率6 .30 % (5 0 7/ 80 4 9) ,其中产超广谱β内酰胺酶(ESBLs)菌株12 1株,占2 3.87% ;不产ESBLs大肠埃希菌与产ESBLs大肠埃希菌对临床常用抗菌药物的耐药率均逐年上升(P <0 .0 1)。结论 大肠埃希菌对临床常用抗菌药物的耐药率有逐年上升趋势,临床治疗时需根据药敏试验结果合理使用抗菌药物,以减少和延缓其耐药性。
Objective To analyse the drug resistant change of Escherichia coli isolated from clinical samples in a hospital to the commonly used antimicrobial agents. Methods Escherichia coli isolated from clinical samples from 2002 to 2004 and bacterial antimicrobial susceptibility tests were analysed retrospectively. Results Five and seven strains of Escherichia coli were isolated, isolation rate was 6.30% (507/8 049), 121 of which produced β-lactamases ( 23.87% ); antimicrobial resistance of both β-lactamases-producing strains and non-β-lactamases-producing strains increased every year (P< 0.01 ). Conclusion antimicrobial resistance of Escherichia coli increased every year, clinical antimicrobial choice should be according to the results of antimicrobial susceptibility tests to reduce the antimicrobial resistance.
出处
《中国感染控制杂志》
CAS
2005年第3期259-261,共3页
Chinese Journal of Infection Control
关键词
大肠埃希菌
抗菌药物
微生物敏感性试验
抗药性
微生物
Escherichia coli
antimicrobial agents
antimicrobial susceptibility test
drug resistance, microbial
