摘要
限于古代科学技术发展水平,传统中药复方只能以丸、散、膏、丹等传统剂型形式表现;当前多组分中药的研究已成为中医药发展的主要方向之一,但其制剂成药性的研究往往被忽视。该文在提出了多组分中药研究应注意与中医药理论融合及其成药性评价2个关键难点问题的基础上,提出了组分中药理化性质的表征及其与成型工艺相关性、基于方-证-剂对应思想的调释微丸制备技术、基于集合数学模型的调释微丸组分释放评价技术等多组分中药制剂学研究可采用的研究方法与技术。
Due to the limitation of science and technology in ancient times, traditional Chinese medicines （TCMs） could have prepared only in traditional dosage forms, such as pills, powders, ointments and pellets. Though studies on multi-component TCMs have become one of major development orientations of TCM, the druggability of their preparations has always been neglected. On the basis of two key difficulties the integration of studies on multi-component TCMs and TCM theory as well as the evaluation on their druggability, the essay proposes methods and technologies that can be adopted in studies on multi-component TCM preparations, inclu- ding the characteristic physicochemical property of multi-component TCMs and its correlation with forming process, the release-modified micro pill preparation technology based on prescription-symptom-dosage, and the evaluation technology on release of release-modified micro pill components based on mathematical set model.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第5期629-632,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81202923)
上海市教委重点学科项目(J50302)
上海市科委"科技创新行动计划"项目(12401900402)
关键词
组分中药
制剂
调释微丸
释放评价
multi-component traditional Chinese medicine
preparation
release-modified pellet
evaluation on drug release
