摘要
目的:应用挤出滚圆法制备含甘草总黄酮效应组分微丸,采用Eudragit RS 100为包衣材料,制备含甘草总黄酮效应组分缓释微丸。方法:采用M in i G latt流化床底喷包衣法制备包衣微丸,对其包衣工艺及处方进行单因素考察,评价微丸的粉体学性质和体外释放行为。结果:当聚合物包衣增重6%,增塑剂用量为10%时,药物具有明显的缓释作用,体外释放曲线符合Peppas和H iguch i方程。结论:制备的含甘草总黄酮效应组分微丸具备较理想的缓释效果。
Objective: To prepare the glycyrrhiza total flavones effective components pellets by extrusion-spheronization,and to optimize the formulation of glycyrrhiza total flavones effective components sustained release pellets coated with mixed Eudragit RS 100.Methods: The sustained-release pellets of glycyrrhiza total flavones were prepared by Glatt fluid bed technique.The factors influencing the drug release behaviors and their properties were evaluated.Results: The optimal drug sustained-release was shown at the...
出处
《中药材》
CAS
CSCD
北大核心
2008年第3期434-438,共5页
Journal of Chinese Medicinal Materials
基金
上海市重点学科建设项目(T0301)
上海市科委项目(04DZ19841)
