摘要
环丙羧酸(1-环丙基-7-氯-6-氟-1,4-二氢-4-氧化喹啉-3-羧酸)和哌嗪发生亲核取代反应生成环丙沙星,再与盐酸成盐生成盐酸环丙沙星。考察了溶剂类型、反应时间、温度、溶液碱度、纯化方式等因素对产品收率和含量的影响。结果表明,最佳工艺条件为:环丙羧酸与无水哌嗪的质量比为1∶0.9,在130℃反应7 h,收率可达98.9%,含量99.6%,该工艺成本低,收率高,含量高,具有工业化应用前景。
Ciprofloxacin was synthesized with 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinol- olinecarboxylic and piperazine by nueleophilic substitution reaction. Ciprofloxaein with hydroehloride reac- tion producted Ciprofloxacin hydrochloride. The effects of synthesis technology ,such as solvent types,re- action temperature and time, solution alkalinity, refinement modes etc. on the product yield and content were studied. The result showed that the optimum process conditions were as follows：the feed ration is 1：0.9（g/g） ,reaction temperature is 130 ℃ and time is 7 h ,the yield of product is 98.9% and content is 99.6%. This study has the advantage of low cost, high content, high yield, it was applied in industry with good foreground.
出处
《应用化工》
CAS
CSCD
2013年第2期287-290,共4页
Applied Chemical Industry
关键词
环丙羧酸
哌嗪
氟喹诺酮苯
盐酸环丙沙星
纯化
Q-acid
piperazine
fluoroquinolone
ciprofloxacin hydrochloride
purification
