摘要
目的改进盐酸环丙沙星制备中的哌嗪缩合反应。方法根据绿色化学的特点和要求,对环丙沙星合成工艺进行优化,避免了哌嗪缩合反应过程中使用有机溶媒,实现了哌嗪缩合的水相合成。结果及结论后处理过程得到简化,保护了自然环境。
Objective To improve Piperazine condensation reaction in the preparation of Ciprofloxacin hydrochioride. Methods According to the characteristic and demand of Green Chemistry, the synthesis crafts of Ciprofloxacin hydrochioride had been optimized.The improved Piperazine condensation reaction avoided using the organic solvent and realized the aqueous phase synthesis. Reuslts and conclusion This method simplified the post- processing process and protected the natural environment.
出处
《齐鲁药事》
2005年第8期487-489,共3页
qilu pharmaceutical affairs
关键词
绿色化学
氟喹诺酮
盐酸环丙沙星
哌嗪缩合
green chemistry
Fluoroquinolone
Ciprofloxacin hydrochioride
Piperazine condensation
