摘要
以2，4-二氯-5-氟苯乙酮为原料，经草酰化，醚化，胺化，环合，水解，脱碳等反应提出一条合成环丙沙星重要中间体环丙羧酸的新方法，反应条件温和，操作容易控制。并在此过程中制备了四种新化合物。
The research put forward a new synthetic method of cyclopropyl carboxylic acid, theimportant intermediate of ciprofloxacin. The reaction was started with 2,4-dichloro-5-fluoroacetophenone, via oxalylation, etherificahon, alnination, cyclization, hydrolysis and decarbonylation,The reaction temperature was moderate and the operation was easily controlled. Addtional, four newcompounds were synthesized by the suggested method.
出处
《高校化学工程学报》
EI
CAS
CSCD
北大核心
1999年第4期368-371,共4页
Journal of Chemical Engineering of Chinese Universities
