摘要
目的研究单纯性糖耐量异常(IGT)脑梗死患者血同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)水平的改变。方法根据血糖水平及糖耐量试验将756例脑梗死患者分为糖耐量正常组、IGT组及糖尿病组。采用免疫透射比浊法测定血清hs-CRP水平,荧光偏振免疫分析法测定血浆Hcy水平。结果血糖正常组331例,IGT组142例,糖尿病组283例。血Hcy及hs-CRP水平IGT组[(19.17±9.35)μmol/L,(8.0±11.9)μg/ml]及糖尿病组[(20.46±10.56)μmol/L,(7.7±20.7)μg/ml]明显高于血糖正常组[(16.17±7.35)μmol/L,(3.5±9.2)μg/ml](均P<0.001),IGT组与糖尿病组间的差异无统计学意义。结论 IGT脑梗死患者的血Hcy和hs-CRP水平明显升高。
Objective To research the change of levels of blood homocysteine （Hcy） and high-sensitivity C- reactive proteinhs （hs-CRP） in cerebral infarction patients with impaired glucose tolerance （IGT）. Methods According to the levels of blood glucose and glucose tolerance test, 756 cerebral infarction patients were divided into normal glucose tolerance group, IGT group and diabetes mellitus group. The level of serum hs-CRP was measured by immunological transmission turbidimetry, and the level of plasma Hcy was measured by fluorescence polarization immunoassay. Results Normal glucose tolerance group was in 331 cases, IGT group in 142 cases, diabetes mellitus group in 283 cases. The levels of blood Hcy and hs-CRP in IGT group [ （ 19.17 ±9.35） μmol/L, （8.0 ± 11.9）μg/mll and diabetes mellitus group [ （20.46± 10.56） μmol/L, （7.7 ± 20.7 ）μg/ml] were significantly higher than those in the normal glucose tolerance group [ （ 16.17 ± 7.35 ） μmol/L, （3.5 -± 9.2） μg/ml ] （ all P 〈 0. 001 ）. There was no significant difference in the levels of blood Hcy and hs-CRP between IGT group and diabetes mellitus group. Conclusion The levels of blood Hcy and hs-CRP in cerebral infarction patients with IGT are significantly increased.
出处
《临床神经病学杂志》
CAS
北大核心
2013年第1期57-58,共2页
Journal of Clinical Neurology
关键词
脑梗死
糖尿病
单纯性糖耐量异常
同型半胱氨酸
超敏C反应蛋白
cerebral infarction
diabetes mellitus
impaired glucose tolerance
homocysteine
high-sensitivity C-reactive protein
