摘要
目的探讨马来酸依那普利叶酸片对H型高血压脑卒中的预防性应用价值。方法选取我院2012年1月-2015年1月收治的H型高血压患者223例作为研究对象。采用随机数字法分为观察组112例和对照组111例。观察组应用马来酸依那普利叶酸片（规格：10mg/0.8mg/片）,口服,1片/次,1次/d;对照组应用马来酸依那普利片（规格：10mg/片）,口服,1片/次,1次/d。疗程12个月,于第1个月和治疗开始后的每3个月随访一次。比较两组患者治疗后血压的变化,脑卒中的发生率和不良反应的发生率。比较两组患者治疗后血液中Hcy、叶酸、维生素B12水平和CIMT。结果治疗后两组患者SBP和DBP显著下降（P〈0.05）,但是两组患者治疗后SBP和DBP差异无统计学意义（P〉0.05）。治疗后观察组患者血液中Hcy显著低于对照组,叶酸水平显著高于对照组（P〈0.05）,血液中维生素B12水平和CIMT两组之间差异无统计学意义（P〉0.05）。观察组患者脑卒中的发生率显著低于对照组（P〈0.05）。两组患者不良反应发生率差异无统计学意义（P〉0.05）。结论马来酸依那普利叶酸片可以有效降低H型高血压患者血浆中Hcy水平和脑卒中的发生率,预防性应用效果显著,安全可靠,适于临床应用。
Objective To investigate the application value of enalapril maleate folic acid tablets on stroke caused by H-hypertension. Methods 223 cases of H-hypertension patients in our hospital from January 2012 to January 2015 were selected. They were randomly divided into observation group with 112 cases and control group with 111 cases.Patients in observation group was treated with maleic acid enalapril folic acid tablets（specifications：10mg/0.8mg/）,oral,1 tablet/time/d,and patients in control group were treated with enalapril maleate tablets（specification： tablets 10mg/）,oral,1 tablet/time/d. The course of treatment was 12 months,and they were followed up in first months and every 3 months after the start of treatment.The changes of blood pressure, the incidence of stroke and adverse reactions between the two groups were compared.The blood Hcy,folic acid,vitamin B12 levels and CIMT between the two groups of patients after treatment were compared. Results After treatment, SBP and DBP of patients in the two groups decreased significantly（P〈0.05）,but the SBP and DBP were not significantly different（P〈0.05）.The Hcy of observation group was significantly lower than that of the control group, and the level of folic acid of observation group was significantly higher than that of the control group（P〈0.05）.There was no significant difference between the levels of vitamin B12 and CIMT of the two groups（P〉0.05）.The incidence of stroke in the observation group was significantly lower than that in the control group（P〈0.05）.There was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）. Conclusion Enalapril maleate folic acid tablets can effectively reduce the plasma levels of homocysteine and stroke incidence of H-hypertension patients. The preventive application effect is remarkable. It is safe and reliable, and suitable for clinical application.
出处
《中国医药科学》
2016年第13期72-75,共4页
China Medicine And Pharmacy
基金
广东省医学科学技术研究项目(WSTJJ20111212420104197108301704)
