摘要
目的研究脑梗死患者血清瘦素水平的改变及其相关因素。方法测量30例脑梗死患者(脑梗死组)和30例非脑梗死患者(对照组)的体重、腰围、血压及血糖、血脂、尿酸血清瘦素、C-反应蛋白(CRP)水平,用彩色多普勒超声仪检测颈部动脉的内-中膜厚度(IMT)。采用Pearson直线相关分析和多元线性逐步回归分析影响脑梗死患者血清瘦素水平的相关因素。结果脑梗死组的收缩压、舒张压、腰围、颈动脉IMT及CRP、瘦素、低密度脂蛋白(LDL)、总胆固醇水平均显著高于对照组(P<0.05～0.01),而高密度脂蛋白(HDL)显著低于对照组(P<0.01)。相关分析显示,脑梗死患者血清瘦素水平与CRP、LDL水平及IMT呈正相关(r=0.530,r=0.372,r=0.562;P<0.05～0.01),与HDL水平呈负相关(r=-0.364,P<0.05)。多元线性逐步回归分析显示,CRP、IMT是影响血清瘦素水平的独立相关因素(P<0.05～0.01)。结论脑梗死患者的血清瘦素水平明显升高,并且与炎症反应、脂质代谢紊乱及颈动脉粥样硬化有关。
Objective To investigate the change and its correlation factors of serum level of leptin in patients with cerebral infarction （CI）. Method Body weight, waist circumference, blood pressure and the levels of glucose lipids,uric acid, leptin, C-reactive protein （CRP） were measured in 30 cerebral infarction patients （CI group） and 30 patients without cerebral infarction （control group）. The intimate-media thickness （IMT） of carotid artery was measured with uhrasonograpby. The correlation factors which influnce the serum leptin level in CI patients were analyzied by pearson linear correlation and multiple stepwise regression analysis. Results The systolic pressure, diastolic pressure, waist circumference, the IMT of carotid artery and the levels of CRP, leptin, low density lipoprotein （LDL） , total cholesterol in CI group were significantly higher than those in control group （ P 〈 0. 05 - 0. 01 ） , while the level of high density lipoprotein （HDL） was significantly lower than that in control group （P 〈 0. 01 ）. The correlation analyies showed that the level of serum leptin was positively correlated with CRP, LDL and IMT （ r = 0. 530, r = 0. 372, r = 0. 562 ; P 〈 0. 05 - 0. 01 ） , and negativly correlated with HDL （ r = - 0. 364, P 〈 0. 05 ）. Multiple stepwise regression analysis showed that CRP and IMT were independent association factors in influencing serum leptin level （ P 〈 0. 05 - 0. 01 ）. Conclusions The serum level of leptin is significantly increased in CI patients. It is associated with inflammation, lipid metabolism and atherosclerosis.
出处
《临床神经病学杂志》
CAS
北大核心
2013年第1期12-14,共3页
Journal of Clinical Neurology
关键词
脑梗死
瘦素
C-反应蛋白
血脂
颈动脉内-中膜厚度
cerebral infarction
leptin
blood lipids
C-reactive protein
intimate-media thickness
