摘要
目的探讨血尿酸(UA)、胆红素和血脂水平与缺血性脑卒中(CIS)的关系,旨为CIS的防治提供新的理论依据。方法以2009年5月—2010年9月在温岭市第一人民医院住院的230例CIS患者为研究对象(观察组),85例健康体检者(排除脑卒中患者)作为对照组。所有受检者于入院后24 h内空腹抽取静脉血测定血UA、总胆红素(TBiL)、直接胆红素(DBiL)、间接胆红素(IBiL)、胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及脂蛋白a〔Lp(a)〕水平,统计分析两组上述指标的差异,并进行相关分析和多元回归分析。结果 (1)两组受检者在高血压史、糖尿病史、吸烟史及饮酒史方面差异均无统计学意义(P<0.05)。(2)观察组血UA水平高于对照组,差异有统计学意义(P<0.01)。观察组血TBiL、DBiL及IBiL水平较对照组均显著降低(P<0.05)。(3)观察组血TC、LDL-C水平较对照组显著增高(P<0.05),血TG、Lp(a)及HDL-C水平在两组间差别无统计学意义(P>0.05)。(4)CIS患者的血UA与HDL-C水平呈负相关(P<0.05),血DBiL与TG和TC水平亦呈负相关(P<0.05)。(5)多因素回归分析结果显示,在调整其他危险因素后,血UA与CIS的正相关关系依然存在,且有统计学意义〔P<0.01,OR=9.48,95%CI(4.45,7.67)〕。TBiL与CIS呈负相关〔P<0.01,OR=0.36,95%CI(0.22,0.62)〕,IBiL与CIS亦呈负相关〔P<0.01,OR=0.49,95%CI(0.30,0.73)〕。结论血UA、TC、LDL-C水平升高,血TBiL、DBiL及IBiL水平下降是CIS的危险因素;血UA与HDL-C、血DBiL与TG和TC之间存在相互作用,共同促进CIS的发生。
Objective To explore the correlation between serum uric acid（UA）,serum bilirubin,and blood fat and cerebral ischemic stroke（CIS）.Methods Totally 230 CIS patients who were admitted in our hospital from May 2009 to September 2010 were enrolled as the CIS group,and 85 healthy individuals who took physical examinations were enrolled as the control group.The serum levels of UA,total bilirubin（TBIL）,direct bilirubin（TBIL）,indirect bilirubin（IBIL）,total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein（LDL）,high-density lipoprotein（HDL）,and lipoprotein（a）（LP（a））were determined and compared between these two groups.Results These two groups had no significant difference in terms of risk factors including histories of hypertension,diabetes mellitus,smoking,and drinking（P0.05）.The serum UA level was significantly higher in CIS group than in control group（P0.01）,while the serum levels of TBIL,IBIL,and DBIL were significantly lower（P0.05）.The TC and LDL-C significantly increased in CIS group when compared with the control group（P0.05）,while no significant difference was found for TG,Lp（a）,and HDL-C（P0.05）.In CIS group,UA was negatively correlated with HDL-C（P0.05）,and DBIL was negatively correlated with TC and TG（both P0.05）.Multiple regression analysis showed that,after adjusting other risk factors,the positive correlation between serum UA and CIS still existed（P0.01,OR=9.48,95%CI（4.45,17.67））,TBIL was negatively correlated with CIS（P0.01,OR=0.36,95%CI（0.22,0.62））,and so was IBIL（P0.01,OR=0.49,95%CI（0.30,0.73））.Conclusion The increase serum UA,TC,and LDL-C and the decline of serum TBIL,DBIL,and IBIL are the risk factors of CIS.The interactions between serum UA and HDL-C and between serum DBIL and TG/TC stimulate the occurrence of CIS.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第11期1178-1180,共3页
Chinese General Practice
关键词
血尿酸
胆红素
血脂
缺血性脑卒中
Serum uric acid
Bilirubin
Blood fat
Cerebral ischemic stroke
