摘要
目的评价下肢软组织肉瘤(STS)术后调强放射治疗(IMRT)的剂量学优势及近期疗效。方法分析2009年5月至2011年1月在该院采用IMRT治疗大腿STS 28例患者的临床资料。结果常规放射治疗(CRT)和IMRT靶区剂量分布PTV3的平均值分别为(95.4±1.2)%和(98.6±1.1)%,Dmax平均值,IMRT(103.7±2.2)%显著低于CRT(113.2±1.1)%,P<0.05。适形指数均值分别为:0.39±0.03和0.74±0.08。局部控制率92.6%(25/27),总生存率为96.3%(26/27)。股骨及皮肤的晚期不良反应较轻。结论 IMRT具有明显的靶区剂量分布优势,可以减少股骨、皮肤等正常组织器官的照射剂量。
Objective To evaluate the dosimetric superiority of postoperative intensity modulated radiation therapy（IMRT） for soft tissue sarcomas（STS） of the thigh and to observe its short term effect. Methods 28 patients with thigh STS undergoing post- operative IMRT in this hospital from May 2009 to January 2011 were performed the retrospective analysis on the clinical data. Re- suits The planning target volume 3（PTV3） of the conventional radiotherapy（CRT） and IMRT was （95.4±1.2）% and （98.6 ± 1.1） % in average, respectively. The mean Dmax in IMRT was （103. 7 ±2.2）%and significantly lower than （113.2± 1.1）% in CRT（P（0.05）. The mean conformity indexes were （0.39±0.03） and （0.74±0.08） respectively. The local control rate was 92. 6%（25/27） and the total survival rate was 96.3%（26/27）. The late adverse reactions of femur and skin was mild. Conclusion IM- RT has significant superiority of target dose distribution in treating STS and reduces the irradiation doge to the normal tissues and organs such as femur and skin.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第7期763-764,773,共3页
Chongqing medicine
关键词
软组织肿瘤
下肢
调强放射治疗
soft tissue neoplasms
lower exlremity
intensity modulated radiation therapy
toxicities
