摘要
目的:评估体部伽玛刀配合热疗及增敏剂治疗复发及转移性软组织肉瘤的疗效与安全性。方法:选取自2012年1月至2014年3月中国人民解放军海军总医院肿瘤诊疗中心收治的63例复发及转移软组织肉瘤患者。采用立体定向体部伽玛射线放射治疗系统(体部伽玛刀)治疗,处方等剂量线采用55%~70%等剂量线包绕计划靶区;单次剂量4~5.5 Gy/次,治疗10~13次,总放射剂量44~55 Gy。所有患者均给予放射增敏剂治疗,增敏剂使用注射用甘氨双唑钠,每次1.00~1.50 g静脉滴注,隔日1次,伽玛刀治疗前0~3 h给药,共5~6次。30例患者配合热疗,自伽玛刀治疗后开始,每次1 h,每周2次,共6次,每次热疗在伽玛刀治疗后4 h内进行。结果:治疗后3个月总有效率为77.7%;伽玛刀联合增敏组的1、2年局部控制率分别为78.8%和63.6%,1、2年生存率分别为75.7%和63.6%;伽玛刀联合增敏及热疗组的1、2年局部控制率分别为83.6%和70.0%,1、2年生存率分别为80.0%和63.3%;随访期内未见严重放射性并发症。结论:对复发性软组织肉瘤采用伽玛刀配合热疗及增敏剂进行治疗是较有效的局部治疗方式。
Objective： This study investigates the clinical effect of body γ-knife combined with radiosensitizer and/or hyperthermia, for the recurrence of soft tissue sarcoma. Methods： Sixty-three patients with recurrent soft tissue sarcoma from January 2012 to March 2014 were treated by body γ-knife combined with radiosensitizer and/or hyperthermia. The patients were exposed to radiation dose levels of 4-5.5 Gy/fraction （10-13 fractions） with total doses of 44-55 Gy and 55%-70% isodose, including 95% PTV. The radiosensitizer, sodium glycodidazolum （CMNa）, was administered to all patients at 1.00-1.50 g V.D qod at 5-6 fractions 0-3 h before body γ-knife treat- ment. Hyperthermia for 30 patients was delivered during the body γ-knife treatment with two fractions/week for a total of six frac- tions. Results： The total response rate was 77.7% three months after the treatment. The one and two year local control rates were 78.8% and 63.6%, respectively, while the survival rates of patients treated with body γ-knife with radiosensitizer at one and two yearswere 75.7% and 63.6%, respectively. The local control rates at one and two years were 83.6% and 70.0%, respectively, while the surviv- al rates at one and two years for body γ-knife combined with radiosensitizer and hyperthermia treatments were 80.0% and 63.3%, re- spectively. Serious complications of radiotherapy were not observed. Conclusion： Body γ-knife combined with radiosensitizer and/or hyperthermia is effective for recurrent soft tissue sarcoma.
作者
康静波
张余飞
朱奇
李启亮
Jingbo KANG Yufei ZHANG Qi ZHU Qiliang LI(Tumor Diagnosis and Treatment Center, Navy General Hospital, Beijing 100048, China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2017年第1期24-28,共5页
Chinese Journal of Clinical Oncology
关键词
体部伽玛刀
软组织肉瘤
热疗
放射增敏剂
body γ-knife, soft tissue sarcoma, hyperthermia, radiosensitizer
