摘要
目的评价调强放疗与3D-CRT治疗晚期胃癌的近期疗效.方法收集35例胃癌术后患者,其中,20例采用调强技术行放疗,15例采用3D-CRT,放疗同期口服卡倍他滨,采取回顾性分析方法评价毒副反应及近期疗效.结果调强放疗剂量分布优于3D-CRT技术,近期总体有效率达到65.00%,疾病控制率达到85.00%,较3D-CRT组有统计学意义(P<0.05).两组患者在骨髓抑制方面差异不大,但在胃肠道毒性方面调强放疗组则明显优于3D-CRT组,具有统计学意义(P<0.05).结论调强放疗具有明显的靶区剂量分布优势,由此可以明显减少周边脏器的照射计量,降低对正常脏器的影响.本研究证实胃癌术后调强放疗与同期化疗具有很高的安全性.
Objective To evaluate the efficacy of intensity-modulated radiotherapy with 3D-CRT in the treatment of advanced gastric cancer.Method 35 cases of postoperative gastric cancer patients,including 20 cases with emphasis on technology and radiotherapy,15 cases were treated with 3D-CRT,radiotherapy and concomitant oral capecitabine,were taken retrospective analysis method to evaluate toxicity and recent curative effect.Results The dose distribution is superior to the 3D-CRT technology,the recent overall effective rate reached 65.00%,the disease control rate reached 85.00%,significantly higher than that of 3D-CRT group（P0.05）,patients of two groups with little difference in inhibition of gastrointestinal toxicity of intensity-modulated radiotherapy group were significantly better than those in 3D-CRT group with a significant difference in the bone marrow（P0.05）.Conclusion IMRT dose distribution of target has the advantage obviously,thereby significantly reduce the exposure metering surrounding organs,reduce the impact on normal organs.The study confirmed gastric cancer postoperative intensity-modulated radiotherapy and concurrent chemotherapy has high security.
出处
《北华大学学报（自然科学版）》
CAS
2013年第3期319-321,共3页
Journal of Beihua University（Natural Science）
关键词
晚期胃癌
调强放疗
3D-CRT
疗效评价
advanced gastric cancer
intensity-modulated radiotherapy
3D-CRT
efficacy evaluation
